The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances

IF 4.2 3区医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2023-10-12 DOI:10.1007/s10856-023-06755-x

Lili Li, Jianghui Zhao, Fengcang Ma, Daihua He, Ping Liu, Wei Li, Ke Zhang, Xiaohong Chen, Lin Song

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Abstract

In this study, ICA@Mg-ZIF-8 was synthesized by Mg doping in ZIF-8 and loaded with icariin (ICA). The morphologies and phases were observed and analyzed by SEM, XRD, and the release behaviors of Mg, Zn ions and ICA were tested. Its antibacterial and mineralization performances were evaluated. The results showed that ICA@Mg-ZIF-8 has the same morphology and crystal structure as ZIF-8. ICA@Mg-ZIF-8 showed enhanced antibacterial activity against Escherichia coli and Staphylococcus aureus, and the antibacterial rate was increased to 87.7 % and 64.0 %, respectively. The results of in vitro mineralization showed that ICA@Mg-ZIF-8 presented better osteogenic performance promoting the uniform deposition of more calcium and phosphorus in simulated body fluids compared to ZIF-8.

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镁掺杂的载Icariin的ZIF-8及其抗菌和成骨性能。

在本研究中，ICA@Mg-ZIF-8通过在ZIF-8中掺杂镁来合成，并负载了icariin（ICA）。通过SEM、XRD对其形貌和相进行了观察和分析，并测试了Mg、Zn离子和ICA的释放行为。对其抗菌和矿化性能进行了评价。结果表明：ICA@Mg-ZIF-8具有与ZIF-8相同的形态和晶体结构。ICA@Mg-ZIF-8对大肠杆菌和金黄色葡萄球菌的抗菌活性增强，抗菌率分别提高到87.7%和64.0%。体外矿化结果表明：ICA@Mg-ZIF-8与ZIF-8相比，ZIF-8具有更好的成骨性能，促进了模拟体液中更多钙和磷的均匀沉积。

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来源期刊

Journal of Materials Science: Materials in Medicine 工程技术-材料科学：生物材料

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

3.5 months

期刊介绍： The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.