Astaxanthin attenuated the stress-induced intestinal motility disorder via altering the gut microbiota.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS International Journal for Vitamin and Nutrition Research Pub Date : 2023-10-01 Epub Date: 2022-05-30 DOI:10.1024/0300-9831/a000756
Ritsu Yasuda, Kazuhiro Kamada, Takaaki Murakami, Ryo Inoue, Katsura Mizushima, Ryohei Hirose, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Kazuhiro Katada, Kazuhiko Uchiyama, Osamu Handa, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Yuji Naito, Yoshito Itoh
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引用次数: 1

Abstract

Gut microbiota and short-chain fatty acids (SCFAs) are recognized as key factors in the pathophysiology of irritable bowel syndrome. Astaxanthin is a carotenoid with strong antioxidant and anti-inflammatory activities. In this study, we examined the effects of astaxanthin on gut microbiota-, SCFAs-, and corticotropin-releasing factor (CRH)-induced intestinal hypermotility. Male Wistar rats (n=12 per group) were fed a diet with or without 0. 02% (w/w) astaxanthin for four weeks and CRH or saline was administered intravenously. The number of fecal pellets was counted 2 h after injection. Then the rats were sacrificed, and the cecal content were collected 3 h after injection. The number of feces was significantly increased by CRH injection in the control group (2.0 vs. 6.5; p=0.028), but not in the astaxanthin group (1.0 vs. 2.2; p=0.229) (n=6 per group). The cecal microbiota in the astaxanthin group was significantly altered compared with that in the control group. The concentrations of acetic acid (81.1 μmol/g vs. 103.9 μmol/g; p=0.015) and butyric acid (13.4 μmol/g vs. 39.2 μmol/g; p<0.001) in the astaxanthin group were significantly lower than that in the control group (n=12 per group). Astaxanthin attenuates CRH-induced intestinal hypermotility and alters the composition of gut microbiota and SCFAs.

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虾青素通过改变肠道微生物群来减轻应激诱导的肠道运动障碍。
肠道微生物群和短链脂肪酸(SCFA)被认为是肠易激综合征病理生理学的关键因素。虾青素是一种类胡萝卜素,具有较强的抗氧化和抗炎活性。在这项研究中,我们检测了虾青素对肠道微生物群、SCFAs和促肾上腺皮质激素释放因子(CRH)诱导的肠道高动力的影响。雄性Wistar大鼠(每组n=12)被喂食含有或不含有0。02%(w/w)虾青素持续四周,并静脉内给予CRH或生理盐水。在注射后2小时计数粪便颗粒的数量。然后处死大鼠,并在注射后3小时收集盲肠内容物。对照组注射CRH后,粪便数量显著增加(2.0对6.5;p=0.028),但虾青素组没有增加(1.0对2.2;p=0.229)(每组n=6)。与对照组相比,虾青素组的盲肠微生物群发生了显著变化。乙酸(81.1μmol/g vs.103.9μmol/g;p=0.015)和丁酸(13.4μmol/g比对39.2μmol/g,p=0.015)的浓度
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来源期刊
CiteScore
5.00
自引率
4.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds. The editorial and advisory boards include many of the leading persons currently working in this area. The journal is of particular interest to: - Nutritionists - Vitaminologists - Biochemists - Physicians - Engineers of human and animal nutrition - Food scientists
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