Intra-uterine exposure to lower maternal haemoglobin concentration is associated with impaired cognitive function in stunted adolescents: results from a 17-year longitudinal cohort study in Indonesia.

IF 3.5 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY International Journal of Food Sciences and Nutrition Pub Date : 2023-12-01 Epub Date: 2023-12-12 DOI:10.1080/09637486.2023.2267792

Muhammad Asrullah, Hastrin Hositanisita, Monique L'Hoir, Siti Muslimatun, Edith Jm Feskens, Alida Melse-Boonstra

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Abstract

The long-term impact of maternal anaemia on cognitive performance remains unknown. Indonesian longitudinal cohort data of 363 paired pregnant mothers and their 10-14-year-old offspring were used to investigate the association between maternal haemoglobin (Hb) concentration and their offspring's cognitive function (assessed by Raven's Progressive Matrices test) during adolescence. The weighted anaemia prevalence was 49.3% in pregnant mothers and 22.2% in adolescents. Adolescents who were stunted, anaemic, or living in a rural area had significantly lower cognitive scores than their counterparts. Maternal Hb was not associated with adolescent cognitive function (β: 0.14; 95%CI: -0.052-0.340). However, the effect of maternal Hb concentration on offspring's cognitive function was modified by stunting status (β, stunted: 0.44; 95%CI: 0.05-0.82; non-stunted: 0.01; 95%CI: -0.02-0.24). This study shows adverse cognitive outcomes at adolescent age are likely multi-causal and can be partially explained by intra-uterine exposure to low maternal Hb concentrations.

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宫内暴露于母体血红蛋白浓度较低与发育迟缓青少年的认知功能受损有关：印度尼西亚一项17年纵向队列研究的结果。

母亲贫血对认知能力的长期影响尚不清楚。使用363名配对孕妇及其10-14岁子女的印度尼西亚纵向队列数据，研究母亲血红蛋白（Hb）浓度与其子女青春期认知功能（通过Raven的渐进矩阵测试评估）之间的关系。孕妇的加权贫血患病率为49.3%，青少年为22.2%。发育迟缓、贫血或生活在农村地区的青少年的认知得分明显低于同龄人。母亲Hb与青少年认知功能无相关性（β=0.14；95%CI:-0.052-0.340），母亲Hb浓度对后代认知功能的影响受到发育迟缓状态的影响（β，发育迟缓：0.44；95%CI:0.05-0.82；未发育迟缓：0.01；95%CI:-0.02-0.24）。这项研究表明，青少年时期的不良认知结果可能是多种原因造成的，可以部分解释为子宫内暴露于母亲低Hb浓度。

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来源期刊

International Journal of Food Sciences and Nutrition 工程技术-食品科技

CiteScore

7.50

自引率

2.60%

发文量

审稿时长

1 months

期刊介绍： The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.