Research Progress on Immunomodulatory Effects of Poly (Lactic-co- Glycolic Acid) Nanoparticles Loaded with Traditional Chinese Medicine Monomers.

Bocui Song, Qian Chen, Chunyu Tong, Yuqi Li, Shuang Li, Xue Shen, Wenqi Niu, Meihan Hao, Yunfei Ma, Yanhong Wang
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Abstract

Immunomodulatory mechanisms are indispensable and key factors in maintaining the balance of the environment in humans. When the immune function of the immune system is impaired, autoimmune diseases occur. Excessive body fatigue, natural aging of the human body, malnutrition, genetic factors and other reasons cause low immune function, due to which the body is prone to being infected by bacteria or cancer. Clinically, the existing therapeutic drugs still have problems such as high toxicity, long treatment cycle, drug resistance and high price, so we still need to explore and develop a high efficiency and low toxicity drug. Poly(lactic-co-glycolic acid) (PLGA) refers to a nontoxic polymer compound that exhibits excellent biocompatibility. Traditional Chinese medicine (TCM) monomers come from natural plants, and have the characteristics of high efficiency and low toxicity. Applying PLGA to TCM monomers can make up for the defects of traditional dosage forms, improve bioavailability, reduce the frequency and dosage of drug use, and reduce toxicity and side effects, thus having the characteristics of sustained release and targeting. Accordingly, PLGA nanoparticles loaded with TCM monomers have been the focus of development. The previous research on drug loading advantages, preparation methods, and immune regulation of TCM PLGA nanoparticles is summarized in the following sections.

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中药单体负载聚乳酸-乙醇酸纳米粒子免疫调节作用研究进展。
免疫调节机制是维持人类环境平衡不可或缺的关键因素。当免疫系统的免疫功能受损时,就会发生自身免疫性疾病。身体过度疲劳、人体自然衰老、营养不良、遗传因素等原因导致免疫功能低下,身体容易感染细菌或癌症。临床上,现有的治疗药物仍存在毒性大、治疗周期长、耐药性高、价格高等问题,仍需探索开发高效低毒的药物。聚乳酸-羟基乙酸(PLGA)是一种无毒的聚合物化合物,具有良好的生物相容性。中药单体来源于天然植物,具有高效低毒的特点。将PLGA应用于中药单体可以弥补传统剂型的缺陷,提高生物利用度,减少用药频率和用量,降低毒性和副作用,从而具有缓释和靶向性的特点。因此,负载TCM单体的PLGA纳米颗粒一直是开发的重点。以下部分对中药PLGA纳米粒子的载药优势、制备方法和免疫调节等方面的研究进行了综述。
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