Efficacy of sacral transcutaneous electrical nerve stimulation in patients with overactive bladder refractory to anticholinergic treatment: a prospective multi-center study.

M Coronas Soucheiron, I Casal Beloy, F N Villalón Ferrero, O Martín Solé, B Capdevila Vilaró, N González Temprano, L Larreina De la Fuente, M García González, M Carbonell Pradas, S Pérez Bertólez, X Tarrado Castellarnau, L García Aparicio, I Somoza Argibay
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Abstract

Objective: To determine whether sacral transcutaneous electrical nerve stimulation (S-TENS) is an effective treatment in patients refractory to anticholinergic drugs (Achs).

Materials and methods: A prospective multi-center study of patients with overactive bladder (OB) refractory to Achs treated with S-TENS from 2018 to 2021 was carried out. S-TENS was applied over 3 months. Symptom progression was assessed using the voiding calendar and the Pediatric Lower Urinary Tract Symptoms Score (PLUTSS), excluding questions 3 and 4 -referring to enuresis- so that progression of daytime symptoms only (LUTS variable) was analyzed.

Results: 66 patients -50% of whom were female- were included, with a mean age of 9.5 years (range: 5-15). S-TENS significantly lowered PLUTSS (19.1 baseline vs. 9.5 final, p< 0.001) and LUTS (13.1 baseline vs. 4.8 final, p< 0.001). It also reduced the number of mictions (8.5 baseline vs. 6.4 final, p< 0.001), while increasing urine volume in the voiding records (214 ml baseline vs. 258 ml final, p< 0.001). Enuresis was the only variable refractory to S-TENS. Complication rate was 3% (2 patients with dermatitis in the S-TENS application area).

Conclusions: S-TENS is effective and safe in the short-term in patients with OB refractory to Achs. Further studies assessing long-term efficacy and potential relapses are required.

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骶骨经皮电神经刺激对抗胆碱能治疗难治性膀胱过度活动患者的疗效:一项前瞻性多中心研究。
目的:确定骶经皮电神经刺激(S-TENS)是否是抗胆碱能药物(Achs)难治性患者的有效治疗方法。材料和方法:对2018年至2021年接受S-TENS治疗的Achs难治性膀胱过度活动症(OB)患者进行前瞻性多中心研究。S-TENS应用时间超过3个月。使用排尿日历和儿童下尿路症状评分(PLUTSS)评估症状进展,排除问题3和问题4(涉及遗尿),以便仅分析日间症状的进展(LUTS变量)。结果:纳入66名患者,其中50%为女性,平均年龄9.5岁(范围:5-15岁)。S-TENS显著降低PLUTSS(19.1基线vs.9.5最终,P结论:S-TENS在短期内对Achs难治性OB患者有效且安全。需要进一步研究评估长期疗效和潜在复发。
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