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Necrotizing enterocolitis and congenital heart disease: differences in management and prognosis. 坏死性小肠结肠炎和先天性心脏病:管理和预后的差异。
R Mena Marcos, G Guillén Burrieza, A Castrillo Arias, S López Fernández, M Martos Rodríguez, A Montaner Ramón, A Creus, M G López Paredes, J A Molino Gahete

Objectives: Necrotizing enterocolitis (NEC) is a main cause of neonatal morbimortality. Gut prematurity and ischemia-reperfusion injury contribute to NEC and characterize two different scenarios: prematurity and congenital cardiopathy (CC). Our aim is to investigate whether CC worsens NEC gastrointestinal and general prognosis.

Materials and methods: NEC episodes from 2015-2023 were reviewed and classified into CC and non-CC. Patients with focal intestinal perforation were excluded. Data regarding NEC debut and management, surgical timing, intestinal segment involved and short-term outcomes were compared.

Results: Out of 205 neonates, 15 were excluded for unavailable records or uncertain diagnosis. 190 cases were included, 59 with CC. Comparing CC and non-CC, no significant differences were found in weight or age at diagnosis, or NEC stage. Hemodynamic (HD) shock [38.98% vs 24.43% (p <  0.05)] and need for vasoactive support at debut were more frequent in CC patients [44.07% vs 23.66% (p < 0.05)]. No differences were found regarding need for surgery at debut, length of resected intestine or segment affected or days on parenteral nutrition. CC conditioned longer hospital stay [110.8 ± 68.4 days vs 68.4 ± 44.6 (p <  0.05)] and higher mortality [30.5 vs 11.5 (p <  0.05)].

Conclusions: NEC in CC patients presents more HD instability at debut and worse global prognosis, probably due to inherent cardiovascular compromise, but need for surgery, type of intestinal involvement and short-term outcomes are similar to non-CC NEC.

目的:坏死性小肠结肠炎(NEC坏死性小肠结肠炎(NEC)是新生儿死亡的主要原因。肠道早产和缺血再灌注损伤是导致 NEC 的原因,也是两种不同情况的特征:早产和先天性心脏病(CC)。我们的目的是研究CC是否会恶化NEC的胃肠道和总体预后:回顾2015-2023年的NEC病例,并将其分为CC和非CC。排除局灶性肠穿孔患者。比较了有关 NEC 首次发病和处理、手术时机、涉及的肠段和短期预后的数据:结果:在 205 例新生儿中,有 15 例因无法获得记录或诊断不明确而被排除。共纳入 190 例,其中 59 例为 CC。CC 和非 CC 新生儿在体重、诊断时的年龄或 NEC 分期方面没有明显差异。血流动力学(HD)休克[38.98% vs 24.43% (p < 0.05)]和首次就诊时需要血管活性支持在CC患者中更为常见[44.07% vs 23.66% (p 结论:CC患者的血流动力学休克和首次就诊时需要血管活性支持在CC患者中更为常见:CC患者的NEC在首发时表现出更多的高密度脂蛋白血症不稳定性和更差的总体预后,这可能是由于固有的心血管损害,但手术需求、肠道受累类型和短期预后与非CC NEC相似。
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引用次数: 0
Posterior urethral valves: risk factors of progression to end-stage chronic renal disease after 10 years of follow-up. 后尿道瓣膜:10 年随访后发展为终末期慢性肾病的风险因素。
L Díaz Menéndez, I Casal Beloy, S Roldán Pérez, R M Romero Ruiz

Objective: To determine risk factors (RF) of progression to end-stage chronic renal disease (ESCRD) and the need for renal replacement therapy (RRT) in patients with posterior urethral valve (PUV).

Materials and methods: A retrospective case and control study of patients diagnosed with PUV in the 1995-2023 period was carried out. Two study groups were created -RRT vs. no-RRT. Clinical, laboratory, and radiological variables were collected. A bivariate analysis and a binary logistic regression were conducted to detect RFs of the need for RRT.

Results: 127 patients were included, 12.% of whom had undergone RRT (n= 20). Mean follow-up was 9.87 years. Mean age at clinical onset was younger in the RRT group (3 months vs. 1.23 years; p= 0.010). Pathological prenatal ultrasonography (p< 0.001), increased Nadir creatinine levels (p< 0.001) and maximum creatinine levels in the first year of life (p<  0.001), and onset with acute renal insufficiency (p= 0.03) were more frequent in the RRT group. Increased creatinine levels in the first week of life (OR: 4.74) and younger age at clinical onset (OR: 1.2) were the only independent RFs to predict the need for RRT. Diagnostic-therapeutic delay and the presence of UTIs during follow-up are not predictive of the risk of final RRT.

Conclusions: In PUV children, renal functional reserve at birth is the only ESCRD risk predictor. Early clinical onset implies a higher risk of RRT.

目的确定后尿道瓣膜(PUV)患者进展为终末期慢性肾病(ESCRD)的风险因素(RF)以及肾脏替代疗法(RRT)的需求:对 1995-2023 年期间确诊的 PUV 患者进行了病例和对照回顾性研究。设立了两个研究组--RRT 组与无 RRT 组。研究人员收集了临床、实验室和放射学变量。通过双变量分析和二元逻辑回归来检测是否需要 RRT:共纳入 127 名患者,其中 12.% 接受过 RRT(20 人)。平均随访时间为 9.87 年。RRT组的临床发病平均年龄较小(3个月对1.23岁;P= 0.010)。病理产前超声波检查(p< 0.001)、纳底血肌酐水平升高(p< 0.001)和出生后第一年的最高血肌酐水平(p结论:在 PUV 儿童中,出生时的肾功能储备是预测 ESCRD 风险的唯一指标。早期临床发病意味着接受 RRT 的风险更高。
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引用次数: 0
Evaluation of quality of life and satisfaction in patients undergoing laparoscopic Mitrofanoff procedure. 对腹腔镜米特罗凡诺夫手术患者的生活质量和满意度进行评估。
M B Oliver, R Gander, G Fatou Royo, M Aguilera, M López, M Asensio

Objectives: The Mitrofanoff principle has been extensively evaluated in terms of associated morbidity and mortality. However, there is limited literature specifically addressing quality of life (QoL), particularly concerning the laparoscopic procedure. The aim of this study was to assess the impact of laparoscopic appendicovesicostomy (LA) on QoL by using a specific questionnaire targeted at patients and their families.

Materials and methods: This observational and descriptive study involved patients who underwent LA between May 2018 and December 2023. A survey consisting of 29 questions, organized into three sections was used: satisfaction with the surgery, outcomes, and current continence status. Responses were graded according to the Likert scale (1-5) (1 = strongly disagree, 5 = strongly agree).

Results: Of the 29 contacted families, 24 (82.8%) responded. The average age was 12.3 years (SD 4.4), with 75.9% being male. The primary indication for surgery was pain during urethral catheterization (69%). Mean postoperative follow-up was 36.5 months. Regarding satisfaction with surgery: overall satisfaction,hospitalization duration and pain control was rated with a score of 5 by 66.7%, 58.3% and 58.3%, respectively. In terms of outcomes: 54.2% rated aesthetic results with a score of 5, and 83.3% rated improvement in QoL with a score of 4 or 5. Concerning current continence status, 66.6% were very satisfied with the results and reported total absence of leakages or on a very specific occasion (score of 4 or 5).

Conclusions: This study supports the improvement in perceived QoL among patients requiring an LA. Overall satisfaction with the procedure and outcomes related to continence were perceived as very good by both patients and their families.

目的:米特罗凡诺夫原理已在相关发病率和死亡率方面进行了广泛评估。然而,专门针对生活质量(QoL),尤其是腹腔镜手术生活质量的文献却很有限。本研究旨在通过针对患者及其家属的特定问卷,评估腹腔镜阑尾造口术(LA)对生活质量的影响:这项观察性和描述性研究涉及2018年5月至2023年12月期间接受LA手术的患者。调查问卷由 29 个问题组成,分为三个部分:手术满意度、结果和当前失禁状况。根据李克特量表(1-5)(1=非常不同意,5=非常同意)对回答进行评分:结果:在联系的 29 个家庭中,有 24 个(82.8%)做出了回复。平均年龄为 12.3 岁(SD 4.4),75.9% 为男性。手术的主要适应症是导尿时疼痛(69%)。术后平均随访 36.5 个月。在手术满意度方面:66.7%、58.3%和58.3%的患者对手术的总体满意度、住院时间和疼痛控制分别打了5分。在手术效果方面:54.2%的人对美学效果的评分为 5 分,83.3%的人对生活质量的改善评分为 4 分或 5 分。关于目前的尿失禁状况,66.6%的人对结果非常满意,并表示完全没有漏尿或在非常特殊的情况下没有漏尿(4 分或 5 分):这项研究证实,需要接受 LA 的患者的生活质量有所提高。患者及其家属对手术的总体满意度以及与尿失禁相关的结果均认为非常好。
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引用次数: 0
Prenatally diagnosed segmental intestinal dilatation associated with anorectal malformation. 产前诊断为伴有肛门直肠畸形的节段性肠管扩张。
J P Camacho, J E Udaquiola, D H Liberto, P X de la Iglesia, P A Lobos

Introduction: Congenital segmental intestinal dilatation has a low incidence within the differential diagnoses of fetal abdominal cyst masses. Suspicion may arise at prenatal ultrasonography, but diagnosis is confirmed at surgery and subsequently at histopathological analysis. There are various theories available to explain its etiopathogenesis. Association with anorectal malformations is rare.

Clinical case: Newborn prenatally diagnosed with an abdominal cystic mass and diagnosed at birth with an associated anorectal malformation, with postoperative confirmation of segmental intestinal dilatation.

Discussion: Segmental intestinal dilatation should be considered within the differential diagnoses when an abdominal cystic mass is prenatally detected at ultrasonography. Association with anorectal malformations at birth has been described, but it is unusual. Suspicion allows diagnosis and adequate treatment to be established.

导言:先天性节段性肠管扩张在胎儿腹腔囊肿的鉴别诊断中发病率较低。产前超声检查时可能会产生怀疑,但手术及随后的组织病理学分析可确诊。有多种理论可以解释其发病机制。与肛门直肠畸形有关的病例很少见:临床病例:产前诊断为腹部囊性肿块的新生儿,出生时诊断为伴有肛门直肠畸形,术后确诊为节段性肠管扩张:讨论:当产前超声波检查发现腹部囊性肿块时,应在鉴别诊断中考虑节段性肠扩张。出生时与肛门直肠畸形伴发的情况也有描述,但并不常见。通过怀疑可以确诊并进行适当的治疗。
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引用次数: 0
Optimizing pediatric laparoscopic cholecystectomy: trocar reduction with percutaneous gallblader traction. 优化小儿腹腔镜胆囊切除术:通过经皮胆囊牵引减少套管。
G M Gavilanes Salazar, O B Grijalva Estrada, A Sáenz Dorado, I Ibarra Rodríguez, R Ramírez Díaz, J Bueno Recio

Objective: Laparoscopic cholecystectomy is typically carried out using four ports. The objective of this study was to describe the percutaneous gallbladder traction technique, which allows the number of ports to be reduced, thus optimizing the procedure, with a similar exposure of the surgical site.

Materials and methods: 2 pediatric patients with symptomatic cholelithiasis underwent laparoscopic surgery from January 2021 to January 2024. Cholecystectomy was performed using an umbilical port (5 mm, 30-degree scope) and two accessory ports. A laparoscopic loop with a running knot was used to conduct percutaneous gallbladder traction at the right intercostal level.

Results: All surgeries were successfully completed. Mean operating time was 90 minutes. Hospital stay was 1-2 days. Postoperative progression was favorable in all patients.

Conclusions: These results confirm that cholecystectomy with percutaneous gallbladder traction is safe, cost-effective, and easily reproducible, which means it can be an alternative to the classic technique.

目的:腹腔镜胆囊切除术通常使用四个孔进行。本研究的目的是描述经皮胆囊牵引技术,该技术可减少端口数量,从而优化手术过程,同时手术部位的暴露情况相似。材料和方法:2021 年 1 月至 2024 年 1 月期间,2 名患有症状性胆石症的儿科患者接受了腹腔镜手术。胆囊切除术使用一个脐孔(5 毫米,30 度镜)和两个辅助孔进行。使用腹腔镜环形结在右肋间水平进行经皮胆囊牵引:结果:所有手术均顺利完成。平均手术时间为 90 分钟。住院时间为 1-2 天。所有患者术后进展良好:这些结果证实了经皮胆囊牵引胆囊切除术安全、经济、易于重复,这意味着它可以替代传统技术。
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引用次数: 0
Posterior rectal advancement with fistula preservation in patients with anorectal malformation. A multicenter study. 保留肛门直肠畸形患者瘘管的直肠后方推进术。一项多中心研究。
C Ramirez Amorós, C Gine Prades, M San Basilio, M Fanjul, A Sánchez Galán, M J Martínez Urrutia, A Vilanova-Sanchez

Background: Anorectal malformations (ARM) with rectoperineal fistula are mainly repaired with a posterior sagittal anorectoplasty (PSARP), which can be challenging given the proximity of the fistula to the vagina and urethra. The posterior rectal advancement anoplasty (PRAA), preserves the anterior wall of the fistula without leaving an anterior or a posterior sagittal incision. It is indicated for selected cases of ARM with rectoperineal fistula in which the anterior aspect of the fistula is partially surrounded by sphincter complex.

Methods: Multicentre and retrospective study of patients with rectoperineal fistula treated with PRAA. We analysed gender, associated malformations, age, operative time, short and long-term results, and complications.

Results: 18 patients aged 93.5 (1.75-312) days underwent PRAA. Surgical time was 35 (25-45) minutes and feeding was started at 24 (5-48) hours postoperatively. There were no vaginal or urethral injuries, no wound infections or dehiscenses. Throughout the 38 (12.75-45.50) months of follow-up there were no anal strictures. All patients are passing stool, 11 (61%) of them with the need of a low dose stool softener.

Conclusion: Selected patients with rectoperineal fistula can be treated with PRAA with a shorter surgical time and hospital stay. This technique provides good results and lower risk of injury to neighbouring structures.

背景:伴有直肠肛管瘘的肛门直肠畸形(ARM)主要采用后矢状位肛门直肠成形术(PSARP)进行修复,但由于瘘管靠近阴道和尿道,这可能具有挑战性。后直肠推进肛门成形术(PRAA)可保留瘘管前壁,而不留前或后矢状切口。它适用于瘘管前端部分被括约肌复合体包围的部分直肠肛管瘘 ARM 病例:方法:对接受PRAA治疗的肛门直肠瘘患者进行多中心回顾性研究。我们分析了性别、相关畸形、年龄、手术时间、短期和长期效果以及并发症:18名患者接受了PRAA手术,年龄为93.5(1.75-312)天。手术时间为35(25-45)分钟,术后24(5-48)小时开始喂食。无阴道或尿道损伤,无伤口感染或开裂。在 38 个月(12.75-45.50 个月)的随访中,没有出现肛门狭窄。所有患者都能排出粪便,其中 11 人(61%)需要使用小剂量软便剂:结论:部分直肠肛瘘患者可采用 PRAA 进行治疗,手术时间和住院时间较短。结论:部分直肠肛瘘患者可采用 PRAA 手术治疗,手术时间和住院时间较短,效果良好,对邻近结构造成损伤的风险较低。
{"title":"Posterior rectal advancement with fistula preservation in patients with anorectal malformation. A multicenter study.","authors":"C Ramirez Amorós, C Gine Prades, M San Basilio, M Fanjul, A Sánchez Galán, M J Martínez Urrutia, A Vilanova-Sanchez","doi":"10.54847/cp.2024.04.13","DOIUrl":"10.54847/cp.2024.04.13","url":null,"abstract":"<p><strong>Background: </strong>Anorectal malformations (ARM) with rectoperineal fistula are mainly repaired with a posterior sagittal anorectoplasty (PSARP), which can be challenging given the proximity of the fistula to the vagina and urethra. The posterior rectal advancement anoplasty (PRAA), preserves the anterior wall of the fistula without leaving an anterior or a posterior sagittal incision. It is indicated for selected cases of ARM with rectoperineal fistula in which the anterior aspect of the fistula is partially surrounded by sphincter complex.</p><p><strong>Methods: </strong>Multicentre and retrospective study of patients with rectoperineal fistula treated with PRAA. We analysed gender, associated malformations, age, operative time, short and long-term results, and complications.</p><p><strong>Results: </strong>18 patients aged 93.5 (1.75-312) days underwent PRAA. Surgical time was 35 (25-45) minutes and feeding was started at 24 (5-48) hours postoperatively. There were no vaginal or urethral injuries, no wound infections or dehiscenses. Throughout the 38 (12.75-45.50) months of follow-up there were no anal strictures. All patients are passing stool, 11 (61%) of them with the need of a low dose stool softener.</p><p><strong>Conclusion: </strong>Selected patients with rectoperineal fistula can be treated with PRAA with a shorter surgical time and hospital stay. This technique provides good results and lower risk of injury to neighbouring structures.</p>","PeriodicalId":94306,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"37 4","pages":"160-164"},"PeriodicalIF":0.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How far do we want to go? 我们想走多远?
V Ibáñez Pradas
{"title":"How far do we want to go?","authors":"V Ibáñez Pradas","doi":"10.54847/cp.2024.04.09","DOIUrl":"10.54847/cp.2024.04.09","url":null,"abstract":"","PeriodicalId":94306,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"37 4","pages":"145-146"},"PeriodicalIF":0.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovation and challenges: minimally invasive surgery training in Latin America. 创新与挑战:拉丁美洲的微创外科培训。
L Rollan, C Gigena, I Diaz Saubidet, S Valverde, G Bellia-Munzon, C Millán

Objective: Our objective was to assess the current status of minimally invasive surgery (MIS) training in Latin America and to identify the primary hurdles for the acquisition of laparoscopic skills.

Materials and methods: An anonymous survey was launched on various social media in November 2022. Surgeon responses were analyzed.

Results: 131 pediatric surgeons from 98 surgical institutions in 16 Latin-American countries replied to the survey. MIS training during residency was found in 45.9% of the surgeons with >  20 years' experience, and in 95.2% of the surgeons with < 10 years' experience. A median of 3 courses (IQR: 2; 5) had been completed by 116 surgeons (88.5%), 70.2% of them ≤ 3 days long, and 85.4% self-funded. The primary hurdles to attend them were the lack of financial resources and/or the absence of local courses (80%). Virtual courses were regarded as a recommendable option to acquire laparoscopic skills by 100 (76.3%) respondents.

Conclusions: MIS training in Latin America has exponentially increased in the last decades. However, training programs have room for improvement, which means training is highly surgeon-dependent, since courses are selected and self-funded by surgeons themselves.

目的我们的目的是评估拉丁美洲微创手术(MIS)培训的现状,并确定掌握腹腔镜技能的主要障碍:2022 年 11 月,在各种社交媒体上发起了一项匿名调查。对外科医生的回复进行了分析:来自 16 个拉美国家 98 个外科机构的 131 名小儿外科医生回复了调查。45.9%拥有20年以上经验的外科医生和95.2%有结论的外科医生在实习期间接受了MIS培训:过去几十年来,拉丁美洲的 MIS 培训急剧增加。然而,培训计划仍有改进的余地,这意味着培训高度依赖于外科医生,因为课程是由外科医生自己选择和自费的。
{"title":"Innovation and challenges: minimally invasive surgery training in Latin America.","authors":"L Rollan, C Gigena, I Diaz Saubidet, S Valverde, G Bellia-Munzon, C Millán","doi":"10.54847/cp.2024.04.10","DOIUrl":"10.54847/cp.2024.04.10","url":null,"abstract":"<p><strong>Objective: </strong>Our objective was to assess the current status of minimally invasive surgery (MIS) training in Latin America and to identify the primary hurdles for the acquisition of laparoscopic skills.</p><p><strong>Materials and methods: </strong>An anonymous survey was launched on various social media in November 2022. Surgeon responses were analyzed.</p><p><strong>Results: </strong>131 pediatric surgeons from 98 surgical institutions in 16 Latin-American countries replied to the survey. MIS training during residency was found in 45.9% of the surgeons with >  20 years' experience, and in 95.2% of the surgeons with < 10 years' experience. A median of 3 courses (IQR: 2; 5) had been completed by 116 surgeons (88.5%), 70.2% of them ≤ 3 days long, and 85.4% self-funded. The primary hurdles to attend them were the lack of financial resources and/or the absence of local courses (80%). Virtual courses were regarded as a recommendable option to acquire laparoscopic skills by 100 (76.3%) respondents.</p><p><strong>Conclusions: </strong>MIS training in Latin America has exponentially increased in the last decades. However, training programs have room for improvement, which means training is highly surgeon-dependent, since courses are selected and self-funded by surgeons themselves.</p>","PeriodicalId":94306,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"37 4","pages":"147-151"},"PeriodicalIF":0.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Limitations and complications of robotic urological surgery in younger children: debunking old beliefs. 低龄儿童机器人泌尿外科手术的局限性和并发症:破除旧观念。
J González-Cayón, A Parente, J I Garrido, V Vargas, R M Paredes

Introduction: Even though certain technical limitations associated with the small size of the patients were taken for granted in the advent of pediatric robotic surgery, we could now be facing a paradigm shift challenging these old beliefs.

Materials and methods: A retrospective study of patients undergoing Da-Vinci-Xi(IS4000)-assisted urological surgery from May 2022 to October 2023 was carried out. Patients were divided into two groups -Group A < 15 kg and Group B ≥ 15 kg. Operating times, hospital stay, and intra- and postoperative complications were compared.

Results: 17 patients (9 in Group A, 8 in Group B) underwent surgery. Median age was 29 months (A) and 109 months (B) (p< 0.001). Median weight was 12.0 kg (A) and 31.5 kg (p< 0.001). Operating time was 162 min (A) and 130 min (p= 0.203). Console time was 99 min (A) and 70 min (B) (p= 0.065). Mean hospital stay was 2 days (A) and 3 days (B) (p= 0.41). No differences were found in terms of intraoperative (p= 0.453) or postoperative (p= 0.485) complications.

Conclusions: Even though operating on younger children seemed more complicated than on older ones in the advent of robotic surgery, the results in our series were similar. The fact patients under 12 months of age were not included means larger studies are required to prove this.

导言:尽管在小儿机器人手术出现之初,与患者体型小相关的某些技术限制被认为是理所当然的,但现在我们可能正面临着范式转变,挑战着这些旧观念:尽管在小儿机器人手术问世之初,与患者体型小相关的某些技术限制被认为是理所当然的,但现在我们可能正面临着范式转变,挑战着这些旧观念:对2022年5月至2023年10月期间接受达芬奇-Xi(IS4000)辅助泌尿外科手术的患者进行回顾性研究。患者被分为两组--A 组 结果17名患者(A组9名,B组8名)接受了手术。中位年龄分别为 29 个月(A 组)和 109 个月(B 组)(p 结论:尽管在机器人手术出现后,为年龄较小的儿童进行手术似乎比为年龄较大的儿童进行手术更为复杂,但我们的系列研究结果却相似。12个月以下的患者没有包括在内,这意味着需要更大规模的研究来证明这一点。
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引用次数: 0
Late effects of Wilms' tumor treatment. 威尔姆斯肿瘤治疗的后期影响。
S Silvente Bernal, O Girón Vallejo, A Sánchez Sánchez, C Menacho Hernández, J Rodón Berrío, B A Parra Gelder

Introduction: Wilms' tumor (WT) is the most frequent renal tumor in childhood. Therapeutic management progression has increased survival rates, and as a result, long-term adverse effects.

Materials and methods: A descriptive retrospective study of a case series from 1977 to 2023 was carried out. The characteristics of the treatments received and the adverse effects listed on medical records were analyzed via phone surveys.

Results: 50 patients (25 boys-25 girls) with a mean age of 3.6 years (3 months-11 years) at diagnosis were included. Most of them (94%) were treated according to the protocol established by the European standards of pediatric oncology, which are characterized by the use of neoadjuvant chemotherapy. In one patient, the American treatment scheme was followed. The most common drugs used were vincristine and actinomycin D (78%). Only 12 patients (28%) received anthracyclines. Unilateral nephrectomy was the most frequent surgical technique (84%). Renal disorders were the most common (46%). However, the occurrence of second neoplasias (9%) and reproductive disorders (8% between boys and girls) had a greater impact on patients' quality of life. Multiple - cardiac (23%), endocrine (26%), and pulmonary (15%) - disorders associated with the treatments received were reported.

Conclusions: WT treatment has an impact on health. Adequate and rigorous surgery, close follow-up, and limiting chemotherapy doses and radiation exposure can minimize long-term sequels.

导言Wilms'肿瘤(WT)是儿童时期最常见的肾脏肿瘤。治疗方法的进步提高了患者的生存率,但同时也带来了长期的不良影响:对 1977 年至 2023 年的一系列病例进行了描述性回顾研究。结果:50 名患者(25 名男孩-25 名女孩)接受了治疗:共纳入 50 名患者(25 名男孩-25 名女孩),确诊时平均年龄为 3.6 岁(3 个月-11 岁)。其中大部分患者(94%)按照欧洲儿科肿瘤标准制定的方案进行治疗,该方案的特点是使用新辅助化疗。一名患者采用了美国的治疗方案。最常用的药物是长春新碱和放线菌素D(78%)。只有12名患者(28%)接受了蒽环类药物治疗。单侧肾切除术是最常用的手术方法(84%)。肾功能紊乱最常见(46%)。然而,二次肿瘤(9%)和生殖系统疾病(男孩和女孩各占 8%)的发生对患者的生活质量影响更大。有报告称,与所接受的治疗相关的多种疾病--心脏疾病(23%)、内分泌疾病(26%)和肺部疾病(15%):结论:WT 治疗对健康有影响。充分而严格的手术、密切的随访、限制化疗剂量和放射线照射可最大限度地减少长期后遗症。
{"title":"Late effects of Wilms' tumor treatment.","authors":"S Silvente Bernal, O Girón Vallejo, A Sánchez Sánchez, C Menacho Hernández, J Rodón Berrío, B A Parra Gelder","doi":"10.54847/cp.2024.03.13","DOIUrl":"https://doi.org/10.54847/cp.2024.03.13","url":null,"abstract":"<p><strong>Introduction: </strong>Wilms' tumor (WT) is the most frequent renal tumor in childhood. Therapeutic management progression has increased survival rates, and as a result, long-term adverse effects.</p><p><strong>Materials and methods: </strong>A descriptive retrospective study of a case series from 1977 to 2023 was carried out. The characteristics of the treatments received and the adverse effects listed on medical records were analyzed via phone surveys.</p><p><strong>Results: </strong>50 patients (25 boys-25 girls) with a mean age of 3.6 years (3 months-11 years) at diagnosis were included. Most of them (94%) were treated according to the protocol established by the European standards of pediatric oncology, which are characterized by the use of neoadjuvant chemotherapy. In one patient, the American treatment scheme was followed. The most common drugs used were vincristine and actinomycin D (78%). Only 12 patients (28%) received anthracyclines. Unilateral nephrectomy was the most frequent surgical technique (84%). Renal disorders were the most common (46%). However, the occurrence of second neoplasias (9%) and reproductive disorders (8% between boys and girls) had a greater impact on patients' quality of life. Multiple - cardiac (23%), endocrine (26%), and pulmonary (15%) - disorders associated with the treatments received were reported.</p><p><strong>Conclusions: </strong>WT treatment has an impact on health. Adequate and rigorous surgery, close follow-up, and limiting chemotherapy doses and radiation exposure can minimize long-term sequels.</p>","PeriodicalId":94306,"journal":{"name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","volume":"37 3","pages":"116-122"},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
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