Characterizing the heterogeneity of membrane liquid-ordered domains

IF 1.8 4区物理与天体物理 Q4 CHEMISTRY, PHYSICAL The European Physical Journal E Pub Date : 2023-10-17 DOI:10.1140/epje/s10189-023-00359-7

Tanmoy Sarkar, Oded Farago

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Abstract

We use a lattice model of a ternary mixture containing saturated and unsaturated lipids with cholesterol (Chol), to study the structural properties characterizing the coexistence between the liquid-disordered and liquid-ordered phases. Depending on the affinity of the saturated and unsaturated lipids, the system may exhibit macroscopic (thermodynamic) liquid–liquid phase separation or be divided into small-size liquid-ordered domains surrounded by a liquid-disordered matrix. In both cases, it is found that the nanoscale structure of the liquid-ordered regions is heterogeneous, and that they are partitioned into Chol-rich sub-domains and Chol-free, gel-like, nano-clusters. This emerges as a characteristic feature of the liquid-ordered state, which helps distinguishing between liquid-ordered domains in a two-phase mixture, and similar-looking domains in a one-phase mixture that are rich in saturated lipids and Chol, but are merely thermal density fluctuations. The nano-structure heterogeneity of the liquid-ordered phase can be detected by suitable experimental spectroscopic methods and is observed also in atomistic computer simulations.

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表征膜-液体有序域的不均匀性。

我们使用含有饱和和不饱和脂质与胆固醇（Chol）的三元混合物的晶格模型来研究表征液体无序相和液体有序相共存的结构性质。根据饱和和不饱和脂质的亲和力，该系统可能表现出宏观（热力学）液-液相分离，或者被划分为被液体无序基质包围的小尺寸液体有序域。在这两种情况下，都发现液体有序区域的纳米级结构是不均匀的，并且它们被划分为富含胆碱的亚结构域和不含胆碱的凝胶状纳米团簇。这是液体有序状态的一个特征，有助于区分两相混合物中的液体有序结构域和单相混合物中的类似结构域，前者富含饱和脂质和胆碱，但仅为热密度波动。液相有序相的纳米结构异质性可以通过合适的实验光谱方法检测，也可以在原子计算机模拟中观察到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The European Physical Journal E CHEMISTRY, PHYSICAL-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

2.60

自引率

5.60%

发文量

审稿时长

3 months

期刊介绍： EPJ E publishes papers describing advances in the understanding of physical aspects of Soft, Liquid and Living Systems. Soft matter is a generic term for a large group of condensed, often heterogeneous systems -- often also called complex fluids -- that display a large response to weak external perturbations and that possess properties governed by slow internal dynamics. Flowing matter refers to all systems that can actually flow, from simple to multiphase liquids, from foams to granular matter. Living matter concerns the new physics that emerges from novel insights into the properties and behaviours of living systems. Furthermore, it aims at developing new concepts and quantitative approaches for the study of biological phenomena. Approaches from soft matter physics and statistical physics play a key role in this research. The journal includes reports of experimental, computational and theoretical studies and appeals to the broad interdisciplinary communities including physics, chemistry, biology, mathematics and materials science.