Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis

IF 9.3 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine & Growth Factor Reviews Pub Date : 2024-02-01 DOI:10.1016/j.cytogfr.2023.10.002

Eslam E Saad , Rachel Michel , Mostafa A. Borahay

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Abstract

Uterine fibroids (UF), also called uterine leiomyoma, is one of the most prevalent uterine tumors. UF represents a serious women's health global problem with a significant physical, emotional, and socioeconomic impact. Risk factors for UF include racial disparities, age, race, hormonal factors, obesity, and lifestyle (diet, physical activity, and stress. There are several biological contributors to UF pathogenesis such as cellular proliferation, angiogenesis, and extracellular matrix (ECM) accumulation. This review addresses tumor immune microenvironment as a novel mediator of ECM deposition. Polarization of immune microenvironment towards the immunosuppressive phenotype has been associated with ECM deposition. Immunosuppressive cells include M2 macrophage, myeloid-derived suppressor cells (MDSCs), and Th17 cells, and their secretomes include interleukin 4 (IL-4), IL-10, IL-13, IL-17, IL-22, arginase 1, and transforming growth factor-beta (TGF-β1). The change in the immune microenvironment not only increase tumor growth but also aids in collagen synthesis and ECM disposition, which is one of the main hallmarks of UF pathogenesis. This review invites further investigations on the change in the UF immune microenvironment as well as a novel targeting approach instead of the traditional UF hormonal and supportive treatment.

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免疫抑制肿瘤微环境与子宫肌瘤：在胶原合成中的作用。

子宫肌瘤（UF），也称为子宫平滑肌瘤，是最常见的子宫肿瘤之一。UF是一个严重的全球妇女健康问题，具有重大的身体、情感和社会经济影响。UF的风险因素包括种族差异、年龄、种族、激素因素、肥胖和生活方式（饮食、体育活动和压力）。UF的发病机制有几个生物学因素，如细胞增殖、血管生成和细胞外基质（ECM）积累。这篇综述将肿瘤免疫微环境作为ECM沉积的新介质。免疫微环境向免疫抑制表型的极化与ECM沉积有关。免疫抑制细胞包括M2巨噬细胞、骨髓源性抑制细胞（MDSCs）和Th17细胞，其分泌体包括白细胞介素4（IL-4）、IL-10、IL-13、IL-17、IL-22、精氨酸酶1和转化生长因子β（TGF-β1）。免疫微环境的变化不仅增加了肿瘤的生长，而且有助于胶原蛋白的合成和ECM的处理，这是UF发病机制的主要特征之一。这篇综述邀请对UF免疫微环境的变化进行进一步的研究，并提出一种新的靶向方法来取代传统的UF激素和支持性治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.

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