Cellulose Acetate-Based Wound Dressings Loaded with Bioactive Agents: Potential Scaffolds for Wound Dressing and Skin Regeneration.

Sindi P Ndlovu, Sibusiso Alven, Kula Hlalisa, Blessing A Aderibigbe
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Abstract

Wound healing and skin regeneration are major challenges in chronic wounds. Among the types of wound dressing products currently available in the market, each wound dressing material is designed for a specific wound type. Some of these products suffer from various shortcomings, such as poor antibacterial efficacy and mechanical performance, inability to provide a moist environment, poor permeability to oxygen and capability to induce cell migration and proliferation during the wound healing process. Hydrogels and nanofibers are widely reported wound dressings that have demonstrated promising capability to overcome these shortcomings. Cellulose acetate is a semisynthetic polymer that has attracted great attention in the fabrication of hydrogels and nanofibers. Loading bioactive agents such as antibiotics, essential oils, metallic nanoparticles, plant extracts, and honey into cellulose acetate-based nanofibers and hydrogels enhanced their biological effects, including antibacterial, antioxidant, and wound healing. This review reports cellulose acetate-based hydrogels and nanofibers loaded with bioactive agents for wound dressing and skin regeneration.

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载有生物活性剂的醋酸纤维素伤口敷料:伤口敷料和皮肤再生的潜在支架。
伤口愈合和皮肤再生是慢性伤口的主要挑战。在目前市场上可用的伤口敷料产品类型中,每种伤口敷料材料都是为特定的伤口类型设计的。这些产品中的一些存在各种缺点,例如抗菌功效和机械性能差、无法提供潮湿的环境、对氧气的渗透性差以及在伤口愈合过程中诱导细胞迁移和增殖的能力差。水凝胶和纳米纤维是广泛报道的伤口敷料,它们已经证明了克服这些缺点的有希望的能力。醋酸纤维素是一种半合成聚合物,在水凝胶和纳米纤维的制备中备受关注。将抗生素、精油、金属纳米颗粒、植物提取物和蜂蜜等生物活性剂加载到基于醋酸纤维素的纳米纤维和水凝胶中,增强了其生物效应,包括抗菌、抗氧化和伤口愈合。这篇综述报道了用于伤口敷料和皮肤再生的基于乙酸纤维素的水凝胶和负载有生物活性剂的纳米纤维。
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