Strategies Toward the Catalyst-Free α-C–H Functionalizations of Tertiary Amines

IF 7.1 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Topics in Current Chemistry Pub Date : 2023-05-03 DOI:10.1007/s41061-023-00424-x
Mohit L. Deb, Pranjal K. Baruah
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Abstract

α-C–H functionalization of tertiary amines has been a highly studied field for the past two decades because several important nitrogen containing heterocycles or compounds can be synthesized through this strategy. Though transition metal catalysts and some metal-free catalysts are mainly used for these reactions, a few catalyst-free reactions have recently been efficiently performed. Catalyst-free reactions are cost-effective, less sensitive to air/moisture, easier to operate, have a simple purification process, and are relatively environment-friendly. In this article, we have summarized all the α-C–H functionalization reactions of tertiary amines performed without using any external catalysts. The content of this article will undoubtedly encourage readers to do more work in this area.

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叔胺无催化剂α-C-H官能化的研究策略
叔胺的α-C-H功能化在过去的二十年里一直是一个高度研究的领域,因为通过这种策略可以合成几种重要的含氮杂环或化合物。虽然过渡金属催化剂和一些无金属催化剂主要用于这些反应,但近年来一些无催化剂的反应也得到了有效的实现。无催化剂反应具有成本效益高、对空气/水分不敏感、操作简单、净化过程简单、相对环保等优点。本文综述了在不使用任何外部催化剂的情况下叔胺的α-C-H功能化反应。这篇文章的内容无疑会鼓励读者在这方面做更多的工作。图形抽象
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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry Chemistry-General Chemistry
CiteScore
13.70
自引率
1.20%
发文量
48
期刊介绍: Topics in Current Chemistry is a journal that presents critical reviews of present and future trends in modern chemical research. It covers all areas of chemical science, including interactions with related disciplines like biology, medicine, physics, and materials science. The articles in this journal are organized into thematic collections, offering a comprehensive perspective on emerging research to non-specialist readers in academia or industry. Each review article focuses on one aspect of the topic and provides a critical survey, placing it in the context of the collection. Selected examples highlight significant developments from the past 5 to 10 years. Instead of providing an exhaustive summary or extensive data, the articles concentrate on methodological thinking. This approach allows non-specialist readers to understand the information fully and presents the potential prospects for future developments.
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