Multicomponent Reactions Using C,N-Binucleophilic Nature of Aminopyrazoles: Construction of Pyrazole-Fused Heterocycles

IF 7.1 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Topics in Current Chemistry Pub Date : 2023-05-26 DOI:10.1007/s41061-023-00427-8
Tasneem Parvin
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Abstract

Synthesis of pyrazole-fused heterocycles has gained considerable attention in recent years due to their wide applications in medicinal chemistry. Aminopyrazoles are versatile building blocks for the synthesis of pyrazole-fused heterocycles by multicomponent reactions. Due to the presence of multiple reaction sites, they have fascinating chemical reactivity. Thus, they have been extensively used in multicomponent reactions for the construction of pyrazole-fused heterocycles. Although few review articles on the preparation and applications of aminopyrazoles are known in the literature, to date there is no dedicated review article on the construction of pyrazole-fused heterocycles exploring the reactivity of amino pyrazoles as C,N-binucleophiles in multicomponent reactions. Considering this, herein the multicomponent reactions for the construction of pyrazole-fused heterocycles exploring C,N-binucleophilic nature of amino pyrazoles have been reported.

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利用氨基吡唑的C, n -双亲核性质的多组分反应:吡唑融合杂环的构建
近年来,吡唑类杂环化合物的合成因其在药物化学中的广泛应用而备受关注。氨基吡唑是通过多组分反应合成吡唑-杂环化合物的通用构件。由于存在多个反应位点,它们具有迷人的化学反应活性。因此,它们在多组分反应中被广泛用于构建吡唑-杂环。虽然文献中很少有关于氨基吡唑的制备和应用的综述文章,但迄今为止还没有专门的关于构建吡唑-融合杂环的综述文章,探讨氨基吡唑作为C, n -双亲核试剂在多组分反应中的反应性。考虑到这一点,本文报道了构建吡唑-融合杂环的多组分反应,以探索氨基吡唑的C, n -二亲核性质。图形抽象
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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry Chemistry-General Chemistry
CiteScore
13.70
自引率
1.20%
发文量
48
期刊介绍: Topics in Current Chemistry is a journal that presents critical reviews of present and future trends in modern chemical research. It covers all areas of chemical science, including interactions with related disciplines like biology, medicine, physics, and materials science. The articles in this journal are organized into thematic collections, offering a comprehensive perspective on emerging research to non-specialist readers in academia or industry. Each review article focuses on one aspect of the topic and provides a critical survey, placing it in the context of the collection. Selected examples highlight significant developments from the past 5 to 10 years. Instead of providing an exhaustive summary or extensive data, the articles concentrate on methodological thinking. This approach allows non-specialist readers to understand the information fully and presents the potential prospects for future developments.
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