K. Rhiem, B. Auber, S. Briest, N. Dikow, N. Ditsch, Neda Dragicevic, S. Grill, E. Hahnen, J. Horváth, B. Jaeger, K. Kast, M. Kiechle, E. Leinert, S. Morlot, M. Püsken, Dieter Schäfer, S. Schott, C. Schroeder, U. Siebers-Renelt, C. Solbach, N. Weber-Lassalle, I. Witzel, C. Zeder-Göss, R. Schmutzler
{"title":"Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer","authors":"K. Rhiem, B. Auber, S. Briest, N. Dikow, N. Ditsch, Neda Dragicevic, S. Grill, E. Hahnen, J. Horváth, B. Jaeger, K. Kast, M. Kiechle, E. Leinert, S. Morlot, M. Püsken, Dieter Schäfer, S. Schott, C. Schroeder, U. Siebers-Renelt, C. Solbach, N. Weber-Lassalle, I. Witzel, C. Zeder-Göss, R. Schmutzler","doi":"10.1159/000516376","DOIUrl":null,"url":null,"abstract":"Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer. Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.","PeriodicalId":9310,"journal":{"name":"Breast Care","volume":"17 1","pages":"199 - 207"},"PeriodicalIF":2.0000,"publicationDate":"2021-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000516376","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Breast Care","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000516376","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 10
Abstract
Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk®) for the analysis of risk genes for familial breast and ovarian cancer. Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process. Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the centers of the GC-HBOC from the initial consultation prior to genetic testing to the use of individual risk-adapted preventive/therapeutic measures.
期刊介绍：
''Breast Care'' is a peer-reviewed scientific journal that covers all aspects of breast biology. Due to its interdisciplinary perspective, it encompasses articles on basic research, prevention, diagnosis, and treatment of malignant diseases of the breast. In addition to presenting current developments in clinical research, the scope of clinical practice is broadened by including articles on relevant legal, financial and economic issues.
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