Julio C. González-Rodríguez, Carlos González-Romero, E. Cuevas-Yáñez, J. Vega, C. Jankowski, D. Corona-Becerril
{"title":"Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis","authors":"Julio C. González-Rodríguez, Carlos González-Romero, E. Cuevas-Yáñez, J. Vega, C. Jankowski, D. Corona-Becerril","doi":"10.4236/ijoc.2021.112006","DOIUrl":null,"url":null,"abstract":"Reaction of ethyl \n(Z)-3-(heteroaryl/aryl)-2-((triphenyl-λ5-phosphaneylidene) amino) acrylates \nintermediates with 2,3-thiophenedicarboxaldehyde \nwas used in novel Tandem three \nconsecutive reactions: aza-Wittig, imine condensation and electrophilic heteroaromatic cyclization to obtain a series of \nindolizines. A tentative mechanism of this reaction is proposed.","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"有机化学国际期刊(英文)","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.4236/ijoc.2021.112006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Reaction of ethyl
(Z)-3-(heteroaryl/aryl)-2-((triphenyl-λ5-phosphaneylidene) amino) acrylates
intermediates with 2,3-thiophenedicarboxaldehyde
was used in novel Tandem three
consecutive reactions: aza-Wittig, imine condensation and electrophilic heteroaromatic cyclization to obtain a series of
indolizines. A tentative mechanism of this reaction is proposed.