Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis

Julio C. González-Rodríguez, Carlos González-Romero, E. Cuevas-Yáñez, J. Vega, C. Jankowski, D. Corona-Becerril
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引用次数: 0

Abstract

Reaction of ethyl (Z)-3-(heteroaryl/aryl)-2-((triphenyl-λ5-phosphaneylidene) amino) acrylates intermediates with 2,3-thiophenedicarboxaldehyde was used in novel Tandem three consecutive reactions: aza-Wittig, imine condensation and electrophilic heteroaromatic cyclization to obtain a series of indolizines. A tentative mechanism of this reaction is proposed.
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新的串联三连续反应:氮杂-维蒂希、亚胺缩合和亲电芳香取代策略合成吲唑嗪
将(Z)-3-(杂芳基/芳基)-2-((三苯基-λ5-膦酰亚胺)氨基)丙烯酸酯中间体与2,3-噻吩二甲醛反应,进行了新的串联三步反应:aza-Wittig、亚胺缩合和亲电杂芳环化,得到了一系列中氮茚。提出了这种反应的初步机制。
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