Pub Date : 2024-12-01Epub Date: 2024-12-03DOI: 10.4236/ijoc.2024.144007
Mohammad Al-Masum, Brooklyn Phillips
Cholesterol is a sterol with a four-membered ring structure and a single hydroxyl group attached to one of the rings. It is the active, raw form of cholesterol. Cholesteryl Ester is the inactive form in which cholesterol is esterified to be transported to target organs. The newly developed process of making bulky esters from unprecedented tertiary alcohols is applied to synthesize cholesterol esters successfully. Although cholesterol is a secondary alcohol, it is a very bulky and interesting compound due to its immense application. Usually, specific enzymes catalyze cholesterol to cholesterol ester. This project aims to develop a cross-coupling chemistry process to synthesize cholesterol esters and see the broader application of those new cholesterol esters in chemical biology. The mixture of cholesterol, sodium tert-butoxide, aroyl chloride, the catalyst PdCl2 (dtbpf) complex, and the solvent 1,4-dioxane, when microwaved at 100˚C for 2 hours, works well for the formation of cross-coupling cholesterol ester products in good to high yields.
{"title":"A Novel Synthesis Process of Cholesterol Ester by the Cross-Coupling of Cholesterol and Aroyl Chlorides.","authors":"Mohammad Al-Masum, Brooklyn Phillips","doi":"10.4236/ijoc.2024.144007","DOIUrl":"10.4236/ijoc.2024.144007","url":null,"abstract":"<p><p>Cholesterol is a sterol with a four-membered ring structure and a single hydroxyl group attached to one of the rings. It is the active, raw form of cholesterol. Cholesteryl Ester is the inactive form in which cholesterol is esterified to be transported to target organs. The newly developed process of making bulky esters from unprecedented tertiary alcohols is applied to synthesize cholesterol esters successfully. Although cholesterol is a secondary alcohol, it is a very bulky and interesting compound due to its immense application. Usually, specific enzymes catalyze cholesterol to cholesterol ester. This project aims to develop a cross-coupling chemistry process to synthesize cholesterol esters and see the broader application of those new cholesterol esters in chemical biology. The mixture of cholesterol, sodium tert-butoxide, aroyl chloride, the catalyst PdCl<sub>2</sub> (d<sup>t</sup>bpf) complex, and the solvent 1,4-dioxane, when microwaved at 100˚C for 2 hours, works well for the formation of cross-coupling cholesterol ester products in good to high yields.</p>","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"14 4","pages":"123-127"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/ijoc.2023.133007
J. C. Phelan, M. Strauss
{"title":"2,4-Dinitrophenyl Ether of Polyvinyl Alcohol and Polymer Bound Anionic SIGMA Complexes","authors":"J. C. Phelan, M. Strauss","doi":"10.4236/ijoc.2023.133007","DOIUrl":"https://doi.org/10.4236/ijoc.2023.133007","url":null,"abstract":"","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70727649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/ijoc.2023.131003
Benjamin Dassonneville, F. Hinkel, H. Detert
{"title":"Rhodium Catalyzed [2π + 2π + 2π]-Cycloaddition of Alkynyl-Ynamides and Carbon Disulfide to Indolo-Thiopyrane Thiones","authors":"Benjamin Dassonneville, F. Hinkel, H. Detert","doi":"10.4236/ijoc.2023.131003","DOIUrl":"https://doi.org/10.4236/ijoc.2023.131003","url":null,"abstract":"","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70727519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/ijoc.2023.131002
T. Mineno, Takeya Yamamoto, Tomoya Nobuta, Hisao Kansui
{"title":"Investigation into Protective Groups for Anilino Functionality upon Oxone-Mediated Oxidative Esterification","authors":"T. Mineno, Takeya Yamamoto, Tomoya Nobuta, Hisao Kansui","doi":"10.4236/ijoc.2023.131002","DOIUrl":"https://doi.org/10.4236/ijoc.2023.131002","url":null,"abstract":"","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70727462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/ijoc.2023.131001
Li Wang
{"title":"Synthesis and Antitumor Activity of 3-[2-(4-Hydroxy-Phenyl)-Ethyl]-Benzo[<i>d</i>] Isoxazole-4,6-Diol","authors":"Li Wang","doi":"10.4236/ijoc.2023.131001","DOIUrl":"https://doi.org/10.4236/ijoc.2023.131001","url":null,"abstract":"","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70726933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/ijoc.2023.132004
Tony Wheellyam Pouambeka, V. N’goka, Narcisse Nicaise Obaya, Guy Crépin Enoua, H. Makomo, Qian-Na Zhan
{"title":"Copper-Catalyzed C-C(O)C Bond Cleavage of Monoalkylated <i>β</i>-Diketone: Synthesis of <i>α</i>,<i>β</i>-Unsaturated Ketones","authors":"Tony Wheellyam Pouambeka, V. N’goka, Narcisse Nicaise Obaya, Guy Crépin Enoua, H. Makomo, Qian-Na Zhan","doi":"10.4236/ijoc.2023.132004","DOIUrl":"https://doi.org/10.4236/ijoc.2023.132004","url":null,"abstract":"","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70727189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/ijoc.2023.132005
Y. Tine, Adama Diédhiou, A. Diallo, I. Ndoye, M. Balde, Cheik H. Gaye, Benjamin Ndiaye, A. Wélé, D. Fall
{"title":"Chemotaxonomic Study of the Covid-Organics of Madagascar Based on the Chemical Composition of Their Essential Oils","authors":"Y. Tine, Adama Diédhiou, A. Diallo, I. Ndoye, M. Balde, Cheik H. Gaye, Benjamin Ndiaye, A. Wélé, D. Fall","doi":"10.4236/ijoc.2023.132005","DOIUrl":"https://doi.org/10.4236/ijoc.2023.132005","url":null,"abstract":"","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70727292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/ijoc.2023.132006
Shintaro Suda, Atsunobu Tateno, Daisuke Nakane, T. Akitsu
{"title":"Hirshfeld Surface Analysis for Investigation of Intermolecular Interaction of Molecular Crystals","authors":"Shintaro Suda, Atsunobu Tateno, Daisuke Nakane, T. Akitsu","doi":"10.4236/ijoc.2023.132006","DOIUrl":"https://doi.org/10.4236/ijoc.2023.132006","url":null,"abstract":"","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70727348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ijoc.2022.122007
Mohammad Al-Masum, Reem M. Albeshy, Houra A. Alalwan
{"title":"Pd-Catalyzed Unprecedented Cross-Coupling of Mixed Phenols and Halides for the Synthesis of Aromatic Ethers","authors":"Mohammad Al-Masum, Reem M. Albeshy, Houra A. Alalwan","doi":"10.4236/ijoc.2022.122007","DOIUrl":"https://doi.org/10.4236/ijoc.2022.122007","url":null,"abstract":"","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70726473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ijoc.2022.122008
Mikhail Yu. Gorbachev, Natalia N. Gorinchoy
{"title":"Molecular Orbital Nature of Solubility of Shot Chain n-Alkanes in Water and Their Reaction Rate Constants with Nitronium Cations: A DFT Study","authors":"Mikhail Yu. Gorbachev, Natalia N. Gorinchoy","doi":"10.4236/ijoc.2022.122008","DOIUrl":"https://doi.org/10.4236/ijoc.2022.122008","url":null,"abstract":"","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70726961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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