On the Efficacy of the Gene, Juxtaposed with Another Zinc Finger Protein 1 (JAZF1) in the Development of Type 2 Diabetes Mellitus among Indians

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disorder characterized by pancreatic beta-cell dysfunction and insulin resistance. The present study was designed to understand the association of genetic variations in the JAZF1 gene with T2DM in the Indian population. The polymorphic study was conducted by PCR-RFLP methods. Further, the biochemical parameters were collected for statistical analysis on the semi-structured questionnaire, and correlation with the polymorphism was done by using SPSS software. The significant differences were observed between T2DM cases and controls in triglycerides, HbA1c, T-cholesterol, LDL-C, BMI, systolic and diastolic BP, PPG, FPG, while no significant differences were observed in HDL-C, WHR. Our results suggested that the JAZF1 rs864745 variant is significantly associated with T2D among the Indian population. The present study concludes that the association of genetic variations and biochemical factors play a vital role in T2DM risk and its prevalence.