{"title":"METHOD DEVELOPMENT AND VALIDATION OF FLURBIPROFEN SODIUM BY USING UPLC","authors":"Shraddha V. Tathe, Shivangi Gupta","doi":"10.53879/id.60.05.12864","DOIUrl":null,"url":null,"abstract":"A simple, precise, and accurate ultra-performance liquid chromatography was developed for flurbiprofen sodium on Acquity BEHC18, (50 x 2.1 mm, 1.7 µm) using acetonitrile: water: glacial acetic acid as the mobile phase. The flow rate was 0.2 mL min-1 and effluent was monitored at 254 nm. The retention time for flurbiprofen sodium was found to be 2.3. Developed method was validated for precision, accuracy, linearity range, robustness and ruggedness as per ICH guideline","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"INDIAN DRUGS","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53879/id.60.05.12864","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
A simple, precise, and accurate ultra-performance liquid chromatography was developed for flurbiprofen sodium on Acquity BEHC18, (50 x 2.1 mm, 1.7 µm) using acetonitrile: water: glacial acetic acid as the mobile phase. The flow rate was 0.2 mL min-1 and effluent was monitored at 254 nm. The retention time for flurbiprofen sodium was found to be 2.3. Developed method was validated for precision, accuracy, linearity range, robustness and ruggedness as per ICH guideline
以乙腈:水:冰醋酸为流动相，在Acquity BEHC18 (50 × 2.1 mm, 1.7µm)上建立了一种简单、精确、准确的氟比洛芬钠超高效液相色谱法。流速为0.2 mL min-1，流出液在254 nm处监测。氟比洛芬钠的保留时间为2.3。根据ICH指南验证了所开发方法的精密度、准确度、线性范围、稳健性和耐用性
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