Schiff bases and their metal complexes with biologically compatible metal ions; biological importance, recent trends and future hopes

IF 4.1 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR Reviews in Inorganic Chemistry Pub Date : 2021-11-10 DOI:10.1515/revic-2021-0034

Ezzat Khan, M. Hanif, Muhammad Salim Akhtar

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引用次数: 5

Abstract

Abstract Schiff bases are in the field of medicinal and material chemistry for a long time. There are several advancements from time to time towards facile synthesis and potential applications. As medicines they have been applied as organic molecules as well as their metal complexes. The activities of metal complexes have been found to increase due to increase lipophilicity in comparison to the corresponding free ligand. Besides simple coordination compounds they have been applied as ionic liquid (IL)- supported and IL-tagged species with far enhanced efficiency. Among metal complexes recent advancement deals with photodynamic therapy to treat a number of tumors with fewer side effects. Schiff bases are efficient ligands and their complexes with almost all metal ions are reported. This mini-review article deals with complexes of Schiff bases with biologically compatible metal ions, Co(II), Cu(II), Zn(II), Pd(II), Ag(I), Pt(II) and their potential uses to combat cancerous cells. Strong hopes are associated with photodynamic therapy and IL-tagged and IL-supported Schiff bases and their complexes.

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希夫碱及其与生物相容性金属离子的金属配合物；生物学的重要性、最近的趋势和未来的希望

摘要席夫碱在药物和材料化学领域有着悠久的历史。在易于合成和潜在应用方面不时有一些进展。作为药物，它们已被用作有机分子及其金属络合物。已经发现金属配合物的活性由于与相应的游离配体相比亲脂性的增加而增加。除了简单的配位化合物外，它们还被用作离子液体（IL）负载和IL标记的物种，效率大大提高。在金属配合物中，最近的进展涉及光动力疗法，以治疗一些副作用较少的肿瘤。席夫碱是有效的配体，其与几乎所有金属离子的配合物都有报道。这篇小型综述文章涉及希夫碱与生物相容性金属离子Co（II）、Cu（II），Zn（II）和Pd（II）的配合物，以及它们在对抗癌细胞中的潜在用途。强烈的希望与光动力疗法以及IL标记和IL支持的席夫碱及其复合物有关。

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来源期刊

Reviews in Inorganic Chemistry 化学-分析化学

CiteScore

7.30

自引率

4.90%

发文量

审稿时长

1 months

期刊介绍： Reviews in Inorganic Chemistry (REVIC) is a quarterly, peer-reviewed journal that focuses on developments in inorganic chemistry. Technical reviews offer detailed synthesis protocols, reviews of methodology and descriptions of apparatus. Topics are treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are committed to high quality standards and rapid handling of the review and publication process. The journal publishes all aspects of solid-state, molecular and surface chemistry. Topics may be treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are commited to high quality standards and rapid handling of the review and publication process. Topics: -Main group chemistry- Transition metal chemistry- Coordination chemistry- Organometallic chemistry- Catalysis- Bioinorganic chemistry- Supramolecular chemistry- Ionic liquids