Cryoglobulinemia Type I in Patient with History of Monoclonal Gammopathy of Unknown Significance: A Case Report

A. Mathis, S. Marrone
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Abstract

Cryoglobulinemia is a form of vasculitis causing inflammation of the blood vessels due to aggregated proteins that clump together at cold temperatures, causing damage to skin, muscles, nerves, and other organs. An elderly black female presented with superficial ulceration with overlying eschar within areas of retiform purpura of her bilateral thighs present for 8 months. She was previously diagnosed with vaso-occlusive disease before presenting to our clinic for further evaluation and management. Upon investigation, we have concluded that the patient has cryoglobulinemia type I. 
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有不明意义的单克隆免疫球蛋白病史的I型冷球蛋白血症1例报告
冷球蛋白血症是一种血管炎,由于聚集的蛋白质在低温下聚集在一起,导致血管炎症,对皮肤、肌肉、神经和其他器官造成损伤。一位老年黑人女性,双侧大腿网状紫癜区域出现浅表溃疡,焦痂覆盖,持续8个月。她之前被诊断为血管闭塞性疾病,然后到我们的诊所进行进一步评估和治疗。经过调查,我们得出结论,该患者患有I型冷球蛋白血症。
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