CRISPR-Cas Technology, the Tool of the Future

Alejandro Esquivel Álvarez, Elías Quesada Morales, María Paz Villegas Calero, Daniela Matarrita Brenes, M. F. Rojas Salas, German Madrigal Redondo, Marianela Chavarría Rojas, Eleaneth Baltodano Viales
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Abstract

The CRISPR-Cas system discovered in the eighties consists of a series of RNA proteins that signal and messengers of the immune system in prokaryotic organisms to protect against invading antigens of various sources. After the CRISPR-Cas discovery, many research advances were made in the following decades regarding knowledge, techniques, and applications. This showed the system could edit the DNA in an exact and specific manner, which made it very promising to exploit it in various fields, such as the therapeutic field. New therapies of various diseases, industrial applications, food manufacturing, among others, make its impact quite relevant. The following review will focus on the fundamental understanding and implications of CRISPR-Cas techniques has with an ethical and legal view. In addition, to explore some of the applications present and future in the healthcare department, some methods of drug delivery in gene therapy, and new research that is being developed with the CRISPR-Cas technology.
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CRISPR-Cas技术,未来的工具
80年代发现的CRISPR-Cas系统由一系列RNA蛋白质组成,这些蛋白质是原核生物免疫系统的信号和信使,以抵御各种来源的入侵抗原。CRISPR-Cas发现后,在接下来的几十年里,在知识、技术和应用方面取得了许多研究进展。这表明该系统可以以精确和特定的方式编辑DNA,这使得它在各个领域的开发非常有希望,例如治疗领域。各种疾病的新疗法、工业应用、食品制造等都使其影响非常相关。以下综述将从伦理和法律角度重点介绍CRISPR-Cas技术的基本理解和影响。此外,探索目前和未来在医疗保健部门的一些应用,基因治疗中的一些药物递送方法,以及CRISPR-Cas技术正在开发的新研究。
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