ACTN3 gene variations in various Ethnic populations and its association with Malocclusion – A Literature Review

Abstract

Genetic etiology of Skeletal Malocclusion has been explored extensively over recent years with the advent of advances in molecular technologies. Studies have been reported that the masticatory muscles regulate skeletal development and few recent works of literature report that the muscle growth regulators influence the facial proportions in sagittal and vertical dimensions in Skeletal Class II malocclusion. This review is a humble attempt to highlight the role of one such muscle gene known as ACTN3 and its association with Skeletal Class II malocclusion.