Salsalate Improves Postprandial Glycemic and Some Lipid Responses in Persons With Tetraplegia: A Randomized Clinical Pilot Trial With Crossover Design.

IF 2.4 Q1 REHABILITATION Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-01-01 Epub Date: 2023-08-16 DOI:10.46292/sci22-00033
Jochen Kressler, Armando Mendez, Luisa Betancourt, Mark Nash
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Abstract

Objectives: To investigate the effects of salsalate on fasting and postprandial (PP) glycemic, lipidemic, and inflammatory responses in persons with tetraplegia.

Methods: This study was a randomized, double-blind, cross-over design. It was conducted at a university laboratory. Ten males aged 25 to 50 years with SCI at C5-8 levels for ≥1 year underwent 1 month of placebo and salsalate (4 g/day) treatment. Blood samples were drawn before and 4 hours after breakfast and lunch fast-food meal consumption.

Results: Descriptive statistics indicate that fasting and PP glucose values were reduced with salsalate (pre-post mean difference, 4 ± 5 mg/dL and 8 ± 8 mg/dL, respectively) but largely unchanged with placebo (0 ± 6 mg/dL and -0 ± 7 mg/dL, respectively). Insulin responses were generally reciprocal to glucose, however less pronounced. Fasting free fatty acids were significantly reduced with salsalate (191 ± 216 mg/dL, p = .021) but not placebo (-46 ± 116 mg/dL, p = .878). Results for triglycerides were similar (25 ± 34 mg/dL, p =.045, and 7 ± 29 mg/dL, p = .464). Fasting low-density lipoprotein (LDL) levels were higher after salsalate (-10 ± 12 mg/dL, p = .025) but not placebo (2 ± 9 mg/dL, p = .403) treatment. Inflammatory markers were largely unchanged.

Conclusion: In this pilot trial, descriptive values indicate that salsalate decreased fasting and PP glucose response to fast-food meal challenge at regular intervals in persons with tetraplegia. Positive effects were also seen for some lipid but not for inflammatory response markers. Given the relatively "healthy" metabolic profiles of the participants, it is possible that salsalate's effects may be greater and more consistent in people with less favorable metabolic milieus.

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水杨酸盐改善四肢瘫痪患者餐后血糖和一些脂质反应:一项交叉设计的随机临床试验
目的:探讨水杨酸盐对四肢瘫痪患者空腹和餐后血糖、血脂和炎症反应的影响。方法:采用随机、双盲、交叉设计。实验是在一所大学的实验室进行的。10名年龄在25岁至50岁的男性,C5-8水平的脊髓损伤≥1年,接受1个月的安慰剂和水杨酸盐(4 g/天)治疗。在吃早餐和午餐快餐前和4小时后抽取血样。结果:描述性统计表明,水杨酸盐降低了空腹和PP血糖值(前后平均差异分别为4±5 mg/dL和8±8 mg/dL),但安慰剂基本不变(分别为0±6 mg/dL和- 0±7 mg/dL)。胰岛素的反应通常与葡萄糖呈反比,但不太明显。水salsalate组空腹游离脂肪酸显著减少(191±216 mg/dL, p = 0.021),而安慰剂组无显著减少(- 46±116 mg/dL, p = 0.878)。甘油三酯的测定结果相似(25±34 mg/dL, p =。0.045和7±29 mg/dL, p = .464)。水杨酸盐治疗后空腹低密度脂蛋白(LDL)水平升高(- 10±12 mg/dL, p = 0.025),而安慰剂治疗后空腹低密度脂蛋白(LDL)水平升高(2±9 mg/dL, p = 0.403)。炎症标志物基本不变。结论:在这项试点试验中,描述性值表明,水杨酸盐定期降低四肢瘫痪患者对快餐挑战的空腹和PP葡萄糖反应。对一些脂质也有积极作用,但对炎症反应标志物没有积极作用。考虑到参与者相对“健康”的代谢状况,在代谢环境不太有利的人群中,水杨酸盐的效果可能更大,更一致。
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来源期刊
CiteScore
3.20
自引率
3.40%
发文量
33
期刊介绍: Now in our 22nd year as the leading interdisciplinary journal of SCI rehabilitation techniques and care. TSCIR is peer-reviewed, practical, and features one key topic per issue. Published topics include: mobility, sexuality, genitourinary, functional assessment, skin care, psychosocial, high tetraplegia, physical activity, pediatric, FES, sci/tbi, electronic medicine, orthotics, secondary conditions, research, aging, legal issues, women & sci, pain, environmental effects, life care planning
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