Early Onset Seizures in Vacuolating Megalencephalic Leukoencephalopathy with Subcortical Cysts (MLC-Vander Knaap Disease) in a Brahmin Family

Abstract

commonest causes for symptomatic epilepsy were hypoxic ischemic insult and CNS infections. Majority of the patients were fully controlled on drugs. Fifty percent patients were controlled on monotherapy, 30% were controlled on two drugs, and 18% patients required more than two drugs. The most common drug used was phe-nytoin followed by phenobarbitone and levetiracetam, sodi-um valproate, and carbamazepine. Noncompliance of the drug was found to be the most common cause of the recurrent episodes of seizures followed by sleep deprivation and fever. The incidence of mental retardation was 12% and behavioral disorder was 22%. Loss of memory was reported in 48% of the patients, which was relatively very high. Conclusion: Preventable causes of epilepsy share a significant portion in the etiology of the disease. Maximum patients can be managed at rural center without sophisticated investigations.