Rapid electrochemical device for single-drop point-of-use screening of parathyroid hormone

Ambalika S Tanak, S. Muthukumar, I. Hashim, S. Prasad
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引用次数: 10

Abstract

Aim: Novel electrochemical point-of-use biosensing device for rapid assessment of parathyroid hormone (PTH) levels has been developed. Materials & methods: The analytical nanobiosensor was designed by integrating unique high density semiconducting nanostructured arrays on a flexible sensing surface. Surface modification technique was tailored for enhancing the interaction of nanostructure–biological interface to capture the target PTH level. Results & conclusion: We demonstrate a rapid nanobiosensor to detect PTH in human serum, plasma and whole blood with a limit of detection of 1 pg/ml and a clinically relevant dynamic range from 1 to 1000 pg/ml. This is the first demonstration of detecting PTH as a point-of-use device devoid of sample pretreatment suitable in a surgical setting with high specificity to PTH.
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用于甲状旁腺激素单点使用筛选的快速电化学装置
目的:开发了一种用于快速评估甲状旁腺激素(PTH)水平的新型电化学使用点生物传感装置。材料与方法:分析型纳米生物传感器是通过在柔性传感表面集成独特的高密度半导体纳米结构阵列而设计的。表面修饰技术旨在增强纳米结构-生物界面的相互作用,以捕获目标PTH水平。结果与结论:我们证明了一种快速的纳米生物传感器可以检测人类血清、血浆和全血中的甲状旁腺激素,检测限为1 pg/ml,临床相关动态范围为1至1000 pg/ml。这是首次证明检测PTH是一种无需样品预处理的使用点设备,适用于对PTH具有高特异性的外科手术环境。
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