{"title":"Research progress of narcolepsy","authors":"F. Xiao, Jun Zhang, F. Han","doi":"10.3969/cjcnn.v17i9.1655","DOIUrl":null,"url":null,"abstract":"The discovery of hypothalamus Hypocretin (Hcrt)/Orexin system and its relationship with narcolepsy is one of the major advances in sleep medicine. Hcrt/Orexin is a significant neurotransmitter in the circadian cycle of arousal. Basic research about Hcrt/Orexin system has been applied in clinical practice and the measurement of Hcrt/Orexin in the cerebrospinal fluid (CSF) is the golden criteria and classification basis for diagnosis of narcolepsy. Breakthrough advance has been made in genetic immunology of hypothalamus Hcrt/Orexin neuronal apoptosis of narcolepsy patients. Medications aimed at Hcrt/Orexin receptors are considered to be a novel target in the treatment of sleep disorders. DOI: 10.3969/j.issn.1672-6731.2017.09.004","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"644-647"},"PeriodicalIF":0.0000,"publicationDate":"2017-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国现代神经疾病杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3969/cjcnn.v17i9.1655","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The discovery of hypothalamus Hypocretin (Hcrt)/Orexin system and its relationship with narcolepsy is one of the major advances in sleep medicine. Hcrt/Orexin is a significant neurotransmitter in the circadian cycle of arousal. Basic research about Hcrt/Orexin system has been applied in clinical practice and the measurement of Hcrt/Orexin in the cerebrospinal fluid (CSF) is the golden criteria and classification basis for diagnosis of narcolepsy. Breakthrough advance has been made in genetic immunology of hypothalamus Hcrt/Orexin neuronal apoptosis of narcolepsy patients. Medications aimed at Hcrt/Orexin receptors are considered to be a novel target in the treatment of sleep disorders. DOI: 10.3969/j.issn.1672-6731.2017.09.004
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