中国现代神经疾病杂志最新文献

{"title":"Analysis of related factors for restless legs syndrome in hemodialysis patients","authors":"Ying-ying Shi, Ji-jun Li, Yanli Song, J. Zhang","doi":"10.3969/cjcnn.v18i1.1721","DOIUrl":"https://doi.org/10.3969/cjcnn.v18i1.1721","url":null,"abstract":"Objective To investigate the incidence of restless legs syndrome (RLS) in hemodialysis patients and to analyze the related risk factors.  Methods There were 220 cases of hemodialysis as hemodialysis group and 40 cases of chronic nephrosis as control group. The severity of RLS was measured by International Restless Legs Syndrome Study Group Rating Scale (IRLS). Beck Depression Inventory (BDI) was used to evaluate the status of depression, Epworth Sleepiness Scale (ESS) was used to evaluate excessive daytime sleepiness (EDS), and Insomnia Severity Index (ISI) was used to evaluate the status of insomnia. Univariate and multivariate forward Logistic regression analysis was used to analyze the related risk factors for RLS in hemodialysis patients. Results In hemodialysis group duration ( Z =-9.837, P = 0.000), serum ferritin ( t = 2.847, P = 0.005), incidence rate of RLS ( χ 2 = 10.918, P = 0.001), the proportion of using hypnotic drugs ( χ 2 = 7.669, P = 0.006), IRLS ( t = 2.322, P = 0.020) and ISI ( Z = 4.117, P = 0.001) were significantly higher than control group. Univariate and multivariate forward Logistic regression analysis showed diabetes ( OR = 3.387, 95% CI: 1.538-7.461; P = 0.002), BDI > 9 score ( OR = 2.643, 95% CI: 1.457-4.795; P = 0.001) and ISI > 7 score ( OR = 3.542, 95%CI: 1.939-6.468; P = 0.000) were independent risk factors for RLS in hemodialysis patients.  Conclusions Hemodialysis patients have a high incidence of RLS and insomnia. RLS is closely related with insomnia. Depression plays an important role therein. DOI: 10.3969/j.issn.1672-6731.2018.01.009","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"18 1","pages":"55-59"},"PeriodicalIF":0.0,"publicationDate":"2018-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45054918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study on lorazepam for treating postoperative pain of wound after spinal meningioma surgery","authors":"Yi‐peng Wang, Wen-bin Wang","doi":"10.3969/cjcnn.v17i12.1709","DOIUrl":"https://doi.org/10.3969/cjcnn.v17i12.1709","url":null,"abstract":"Objective To estimate the effect of lorazepam in relieving postoperative wound pain and anxiety after spinal meningioma surgery.  Methods A total of 106 patients underwent spinal meningioma resection with endotracheal general anesthesia. They were randomly divided into lorazepam group (N = 53) and control group (N = 53). Patients in lorazepam group were given lorazepam 0.50 mg one night before surgery and 6 h after surgery, while control group were given compound vitamin B at the same time. Operation time, intraoperative bleeding and wound healing after surgery were recorded. McCormick grade and Self-Rating Anxiety Scale (SAS) were used to evaluate the spinal function and anxiety. At 48 h after surgery, Visual Analogue Scale (VAS) was used to evaluate the degree of postoperative pain.  Results All patients underwent tumor total resection, and spent the perioperative period safely. No complications such as infection happened. Neurological function were relieved to varying degrees and there was no worsening case. Compared with control group, SAS score in lorazepam group was significantly decreased at 48 h after surgery ( P = 0.000). Compared with before surgery, SAS score in lorazepam group was significantly decreased at 48 h after surgery ( P = 0.000). The VAS score at 48 h after surgery in lorazepam group was significantly lower than control group [(5.40 ± 1.24) score vs. (7.15 ± 1.12) score; t = 7.593, P = 0.000].  Conclusions Lorazepam as an antianxiety agent can effectively relieve postoperative pain after spinal meningioma resection. DOI: 10.3969/j.issn.1672-6731.2017.12.011","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"924-928"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49059911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of cerebral hyperperfusion syndrome","authors":"Guangquan Zhang, Shiyi Zhu, Zhi-yong Ji, Pei-quan Zhou, Shancai Xu, Huaizhang Shi","doi":"10.3969/CJCNN.V17I12.1701","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I12.1701","url":null,"abstract":"Cerebral hyperperfusion syndrome (CHS) is a rare syndrome deriving from carotid endovascular treatment with a high mortality. CHS can be derived by carotid endarterectomy (CEA), carotid artery stenting (CAS) and intracranial artery stenting. This review aims to summarize the progress of clinical manifestations, risk factors, pathogenesis, diagnostic criteria, prevention and treatment for CHS in recent years. DOI: 10.3969/j.issn.1672-6731.2017.12.003","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"869-873"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46154401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for in-stent restenosis of vertebral artery origin after stent implantation: a Meta-analysis","authors":"Fangfang Hao, Wenhui Teng, Qingting Hu, Lei Fu, W. Gong, Xian-jun Zhang, Naidong Wang, Yong Zhang","doi":"10.3969/cjcnn.v17i12.1702","DOIUrl":"https://doi.org/10.3969/cjcnn.v17i12.1702","url":null,"abstract":"Objective To systematically review the risk factors for in-stent restenosis (ISR) of vertebral artery origin after sent implantation to provide theoretical foundation for clinical prevention and treatment.  Methods Taking vertebral artery, vertebrobasilar insufficiency, stents, drug-eluting stents, self expandable metallic stents in English and Chinese as key words, retrospective clinical studies about risk factors for ISR of vertebral artery origin were searched by using PubMed, EMBASE/SCOPUS, Cochrane Library, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Data and VIP database from January 1, 1966 to March 30, 2017. Quality assessment and Meta-analysis were made by using Newcastle-Ottawa Scale (NOS) and Stata 12.0 software.  Results The research enrolled 3468 articles in all, from which 11 studies were chosen after excluding duplicates and those not meeting the inclusion criteria. A total number of 1352 patients were divided into ISR group (N = 440) and non-ISR group (N = 912). The ISR incidence rate of smokers was significantly higher than non-smokers ( OR = 2.179, 95%CI: 1.373-3.458; P = 0.001). The differences of bare metal stents (BMS) utilization rate ( OR = 2.072, 95% CI: 1.560-2.753; P = 0.000) and drug-eluting stents (DES) utilization rate ( OR = 0.483, 95% CI: 0.363-0.641; P = 0.000) between ISR group and non-ISR group were statistically significant.  Conclusions Smoking and using BMS are risk factors for ISR of vertebral artery origin, and using DES is protective factor. Due to limited study quality, more high-quality studies are needed to verify this conclusion. DOI: 10.3969/j.issn.1672-6731.2017.12.004","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"874-882"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44302703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary fMRI study on activiation pattern and functional reorganization of motor cortex in acute ischemic stroke patients","authors":"Fanyong Zeng, Zhiqiang Zhang, Fang Yang, Jianping Hu, Qiang Xu, G. Lu","doi":"10.3969/cjcnn.v17i12.1703","DOIUrl":"https://doi.org/10.3969/cjcnn.v17i12.1703","url":null,"abstract":"Objective To observe and explore the activation pattern and functional reorganization mechanism of motor cortex in acute ischemic stroke patients.  Methods A total of 22 patients with first-ever acute ischemic stroke were included in this study. Functional magnetic resonance imaging (fMRI) was used to observe the changing of activation pattern and functional reorganization of motor cortex in finger-tapping task. National Institutes of Health Stroke Scale (NIHSS) and Fugl-Meyer Assessment Scale for Upper Extremity (FMA-UE) were used to evaluate motor function, and neuroelectrophysiology monitored resting motor threshold (RMT). Spearman rank correlation analysis was used to analyze the correlation between activation of region of interest (ROI) and neurological function, motor function and neuroelectrophysiology. Moreover, dynamic causal model (DCM) was used to analyze the intrahemispheric and interhemispheric effective connectivity between brain regions in finger-tapping task. Results Movements of the affected hand showed significant signal activation in the ipsilesional primary motor cortex (M1), premotor cortex (PMC) and bilateral supplementary motor area (SMA), while the contralesional PMC, posterior parietal cortex (PPC) and bilateral cerebellar hemisphere also showed slight activation. Movements of the unaffected hand showed significant activation in the contralesional M1, PMC and SMA, while the ipsilesional SMA and inferior parietal lobule also showed slight activation. The activation value of ipsilesional M1 was negatively correlated with neurological function (NIHSS score; r s = -0.452, P = 0.035) and positively correlated with motor function of upper extremity (FMA-UE score;  r s = 0.543, P = 0.009). The activation value of ipsilesional sensorimotor cortex (SMC) was positively correlated with RMT ( r s = 0.718, P = 0.001). The advantage model of DCM showed bidirectional suppressive influence of connectivity between bilateral M1, negative effective connectivity from contralesional SMA to M1, positive effective connectivity from contralesional SMA to ipsilesional M1 and from ipsilesional SMA to contralesional SMA. The intensity of effective connectivity from contralesional to ipsilesional M1 was negatively correlated with motor function (FMA-UE score;  r s = -0.461, P = 0.047). The intensity of effective connectivity from contralesional SMA to contralesional M1 was positively correlated with motor function (FMA-UE score;  r s = 0.533, P = 0.041).  Conclusions fMRI combined with neurological function, motor function and electrophysiology can be used to observe activation pattern and functional reorganization mechanism of motor cortex in acute ischemic stroke patients, and provide new insights into understanding the motor impairment and functional reorganization after stroke and rehabilitation therapy. DOI: 10.3969/j.issn.1672-6731.2017.12.005","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"883-890"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45920404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of far lateral approach versus presigmoidal approach for exposing inferior clivus by virtual reality technique","authors":"K. Tang, Ya-qun Zhao, Qing Zhou, Ce Liu","doi":"10.3969/CJCNN.V17I12.1706","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I12.1706","url":null,"abstract":"Objective To compare the three-dimensional anatomic differences of far lateral approach versus presigmoidal approach to expose inferior clivus by virtual reality technique.  Methods CT and MRI image data of 15 cadaver heads (30 sides) were inputted into Vitrea virtual reality system to establish three-dimensional anatomy model of posterior cranial fossa. Three points including anterior edges of bilateral tubercula jugulare and tubercula pharyngeum were selected to form a plane. The region of inferior clivus was defined as area under the aforementioned plane. The anterior edge of intersection curve between the plane and the clivus was selected as skull base landmark to expose. The mastoidale and posterior edge of occipital condyle articular surface were selected as craniotomy landmarks of presigmoidal and far lateral approaches. Cylinder with 1 cm diameter was outlined to simulate surgical approach, of which the axis passed through the aforementioned craniotomy landmarks. The superior edge of bottom surface of cylinder on the side of skull base was located in the aforementioned landmark of skull base. Anatomic exposures of the above two approaches were compared by paired t test.  Results The far lateral approach located at the lateral edge of foramen magnum, anterior to the cerebellum, lateral to the brain stem, medial to the jugular bulb, lateral and inferior to the accessory nerve, involved hypoglossal nerve and reached inferior clivus. Bone drilling through presigmoidal approach began with mastoidale. The approach passed through inferior edge of jugular bulb, anterior to the sigmoid sinus, inferior to the accessory nerve, involved hypoglossal nerve at the lateral edge of foramen magnum, reached inferior clivus anterior to the brain stem. The volumes of surgical route [(4629.80 ± 81.00) mm 3 vs. (2622.60 ± 72.58) mm 3 ; t = 91.532,  P = 0.000] and route involving hypoglossal nerve [(10.15 ± 0.17) mm 3 vs. (7.15 ± 0.20) mm 3 ;  t = 52.413, P = 0.000] through presigmoidal approach were more than those through far lateral approach. Osseous structures involved in far lateral approach was more than that in presigmoidal approach [(2362.90 ± 80.18) mm 3 vs. (1851.60 ± 63.62) mm 3 ;  t = 25.714, P = 0.000].  Conclusions Passing through hypoglossal nerve and drilling partial osseous structures will help to avoid cerebellum and brain stem and expose inferior clivus through far lateral approach and presigmoidal approach. DOI: 10.3969/j.issn.1672-6731.2017.12.008","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"905-909"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46354293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis of cerebral venous sinus thrombosis and its combined treatment of anticoagulation and endovascular thrombolysis","authors":"Yun Jiang, X. Chu, Kun-peng Chen, Juan Chen, Daming Wang","doi":"10.3969/CJCNN.V17I12.1704","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I12.1704","url":null,"abstract":"Objective To investigate the clinical and imaging manifestations of cerebral venous sinus thrombosis (CVST), and the clinical effect of combined treatment of anticoagulation and endovascular thrombolysis.  Methods and Results The clinical manifestations of 22 CVST patients were highly variable. Headache (90.91%, 20/22) was the most frequent symptom, and conscious disturbance, seizure and focal neurological deficits were commonly present. Plasma D-dimer level was elevated in 12 patients (54.55%). Lumbar puncture was performed in 14 patients, in whom intracranial hypertension was present in 9 patients (9/14) with no characteristic changes in routine and biochemical examination of cerebrospinal fluid (CSF). Brain CT/MRI and CTV/MRV showed direct signs of CVST in all 22 patients, involving superior sagittal sinus, transverse sinus, sigmoid sinus, straight sinus and cortex veins, parenchymal lesions (infarction, hemorrhage and white matter abnormalities) in 13 patients (59.09%), subarachnoid hemorrhage (SAH) in 2 patients (9.10%) and subdural hematoma in one patient (4.55%). The involved cerebral sinuses revealed by DSA were superior sagittal sinus in 13 patients (59.09% ), transverse sinus in 17 patients (77.27%), sigmoid sinus in 14 patients (63.64%), inferior sagittal sinus in 2 patients (9.10%), straight sinus in 4 patients (18.18%), vein of Galen in one patient (4.55%) and jugular vein in one patient (4.55%). Two thrombosed sinuses were found in 9 patients (40.91% ) and 3 or more thrombosed sinuses in 8 patients (36.36% ). As no clinical improvements and progressive exacerbation were observed several days after heparin sodium intravenous drip or lower molecular weight heparin (LMWH) hypodermic injection with oral warfarin anticoagulant therapy, urokinase thrombolysis in venous sinus or artery was applied in 21 patients (95.45%). After (25.70 ± 12.18) d treatment with anticoagulation, the modified Rankin Scale (mRS) score of 13 patients (59.09% ) reached 0-1, 4 patients (18.18% ) 2 and 5 patients (22.73% ) 3-4, with the total effective rate reaching 77.27% (17/22). Conclusions The severely affected CVST usually have multiple sinus thromboses, deep venous thrombosis and parenchymal lesions. Endovascular thrombolysis together with primary anticoagulation may result in good outcomes in these patients. DOI: 10.3969/j.issn.1672-6731.2017.12.006","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"891-897"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45097684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sellar/suprasellar extraventricular neurocytoma","authors":"Li Zhang, Xueyong Liu, S. Zhang, Yupeng Chen, Xingfu Wang","doi":"10.3969/CJCNN.V17I12.1707","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I12.1707","url":null,"abstract":"Objective To explore the clinicopathological features of extraventricular neurocytoma located in the sellar/suprasellar region.  Methods The clinical manifestations, neuroimaging, histopathological, immunohistochemical and molecular genetic features were retrospectively analyzed in one case of sellar/suprasellar extraventricular neurocytoma, and the related literatures were reviewed.  Results A 27-year-old female presented with intermittent headache, accompanied by blurred vision for 5 months. Head MRI demonstrated a mass with a well-defined margin measuring 3.80 cm × 2.50 cm × 3.40 cm located in the sellar/suprasellar region. The tumor showed isointense to hyperintense signals on T 1 WI and hyper-hypointense mixed signals on T 2 WI, and slightly hyperintense signal on diffusion-weighted imaging (DWI). The pituitary was not shown. A transsphenoidal sellar tumor resection, cerebrospinal fluid (CSF) rhinorrhea repairing and optic decompression were performed. The mass was lightly yellow and tough with abundant blood supply and filled with old hemorrhage. The pituitary tissue was pushed to the left rear. Microscopy examination showed a diffuse invasive growth pattern with neuropil background in some area. The tumor cells were uniform on size and shape with round to oval, exquisite and hyperchromatic nuclei. No mitosis was found. Immunohistochemical staining showed the tumor cells were positive for neuronal nuclei (NeuN) and thyroid transcription factor-1 (TTF-1) in nuclei, calretinin (CR) in nuclei and cytoplasm, synaptophysin (Syn), chromogranin A (CgA), E-cadherin, matrix metalloproteinase-9 (MMP-9) in cytoplasm, and focally positive for S-100 protein (S-100) in nuclei, and neurofilament protein (NF), cytokeratin 8 (CK8) and vimentin (Vim) in cytoplasm. The Ki-67 labeling index was about 3%. The tumor tissue was negative for reticular fiber staining. Molecular genetic analysis showed that isocitrate dehydrogenasel (IDH) gene was not mutated, and 1p/19q was intact in tumor cells. The final pathological diagnosis was extraventricular neurocytoma, WHO grade Ⅱ.  Conclusions Extraventricular neurocytoma located in the sellar/suprasellar region is very rare. The histological features are similar to central neurocytoma in ventricle. Tumor cells were in diffusely invasive growth and were uniform in size and shape, with round nuclei. Fibrillary areas mimicking neurophil and branching thin-walled capillaries can be seen. The differential diagnosis includes pituitary adenoma, oligodendroglioma, clear cell ependymoma, and so on. DOI: 10.3969/j.issn.1672-6731.2017.12.009","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"910-916"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45447645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interhemispheric (pericallosal) lipoma","authors":"T. Han","doi":"10.3969/CJCNN.V17I12.1712","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I12.1712","url":null,"abstract":"2005, 26:1222⁃1223.] Hernandez J, Lackner A, Aye P, Mukherjee K, Tweardy DJ, Mastrangelo MA, Weinstock J, Griffiths J, D'Souza M, Dixit S, Robinson P. Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis. Infect Immun, 2007, 75:1137⁃1143. (收稿日期:2017⁃11⁃04) [17] anxiety of patients receiving renal biopsy. Dang Dai Yi Xue, 2016, 22:117⁃118. [曾艳. 术前综合护理干预对肾穿刺活检术 患者焦虑的影响. 当代医学, 2016, 22:117⁃118.] Xie GZ. Effect of psychological intervention on anxiety and pain in patients undergoing breast cancer operation. Qiqihaer Yi Xue Yuan Xue Bao, 2005, 26:1222⁃1223. [谢桂珍. 心理干预对乳腺 癌手术病人焦虑与疼痛的效果观察. 齐齐哈尔医学院学报, [16]","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"928"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48284642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of butyrylcholinesterase in the pathogenesis of Alzheimer's disease","authors":"Hao-bin Wu, Xu-dong Li, D. Peng, J. Jiao, Yan-feng Li, P. Yu, Yong Ji","doi":"10.3969/CJCNN.V17I12.1711","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I12.1711","url":null,"abstract":"Alzheimer's disease (AD) is a neurodegenerative disease of unknown etiology and pathogenesis. The typical pathological changes of AD include neuritic plaques [NPs, senile plaques (SPs)] with deposition of β-amyloid protein (Aβ) and neurofibrillary tangles (NFTs) due to abnormal aggregation of tau protein. Researches show that cholinergic system is related to AD, and butyrylcholinesterase (BChE) plays an important role in AD. This article reviews the important role of BChE in the pathogenesis of AD. DOI: 10.3969/j.issn.1672-6731.2017.12.013","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"933-936"},"PeriodicalIF":0.0,"publicationDate":"2017-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42214464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}