Analysis of myelogram data in patients with HIV infection and hematopoiesis oppression

Abstract

Objective. To identify risk factors of adverse outcome in patients with HIV infection and cytopenia.Materials and methods. The analyzed group included 30 patients with HIV and two-line cytopenia and pancytopenia. The patients were on inpatient treatment in the Budget Healthcare Institution «CTBD №4», BHCI «Regional Clinical Hospital», Omsk. Results and discussion. Hematopoiesis was found in 14 patients (46,66%), while dyseritropoiesis was noted in 4 patients (13,33%), dysgranulocytopoiesis in 3 patients (10%), cellular rejuvenation of granulocyte series in 2 patients (6,67%), mononuclear cells (involutive forms of megakaryocytes) in 5 patients (13,33%). As HIV progresses the patients experience increasing number and severity of hematological abnormalities in hemograms and myelograms. Early correction of hematopoietic disorders allows to improve the quality of these patients’ life. Myelodysplasia emergence in myelogram in patients with or without ARV therapy statistically differed only in a megakaryocytic germ. The death risk scale of patients with HIV and cytopenia is developed, on the basis of clinical data, obtained results of bone marrow research, based on regression equations.