Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality

IF 3.6 Q2 TOXICOLOGY Toxicon: X Pub Date : 2022-06-01 DOI:10.1016/j.toxcx.2022.100124
Mitchel Otieno Okumu , James Mucunu Mbaria , Joseph Kangangi Gikunju , Paul Gichohi Mbuthia , Vincent Odongo Madadi , Francis Okumu Ochola , Kenneth Narotso Maloba , Joseph Gichuki Nderitu
{"title":"Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality","authors":"Mitchel Otieno Okumu ,&nbsp;James Mucunu Mbaria ,&nbsp;Joseph Kangangi Gikunju ,&nbsp;Paul Gichohi Mbuthia ,&nbsp;Vincent Odongo Madadi ,&nbsp;Francis Okumu Ochola ,&nbsp;Kenneth Narotso Maloba ,&nbsp;Joseph Gichuki Nderitu","doi":"10.1016/j.toxcx.2022.100124","DOIUrl":null,"url":null,"abstract":"<div><p>This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing <em>Naja ashei</em> venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of <em>Naja ashei</em> venom (NAV).</p></div>","PeriodicalId":37124,"journal":{"name":"Toxicon: X","volume":null,"pages":null},"PeriodicalIF":3.6000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590171022000340/pdfft?md5=056b177fce2af29a9113781332daacb4&pid=1-s2.0-S2590171022000340-main.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicon: X","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590171022000340","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 1

Abstract

This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV).

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
三种抗眼镜蛇毒素致人死亡的临床前疗效测试
本研究旨在确定Inoserp、Vins生物制品和南非医学研究所(SAIMR)多价抗蛇毒血清在中和Naja ashei毒液致小鼠死亡中的功效。用有效剂量、中位有效比、效价、归一化效价、体积和中和100 mg NAV所需的抗蛇毒血清瓶数来表示抗蛇毒血清的中和效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Toxicon: X
Toxicon: X Pharmacology, Toxicology and Pharmaceutics-Toxicology
CiteScore
6.50
自引率
0.00%
发文量
33
审稿时长
14 weeks
期刊最新文献
Stress levels, hematological condition, and productivity of plasma-producing horses used for snake antivenom manufacture: A comparison of two industrial bleeding methods Diagnosis of human envenoming by terrestrial venomous animals: Routine, advances, and perspectives Supplementation of polyclonal antibodies, developed against epitope-string toxin-specific peptide immunogens, to commercial polyvalent antivenom, shows improved neutralization of Indian Big Four and Naja kaouthia snake venoms Bioprospection of rattlesnake venom peptide fractions with anti-adipose and anti-insulin resistance activity in vitro A probabilistic hazard assessment for cyanobacterial toxins accounting for regional geography and water body trophic status
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1