The Role of Undifferentiated Connective Tissue Dysplasia in the Development and Clinic of Non-Traumatic Subarachnoid Hemorrhage

Abstract

Some researches of recent years have described the changes in cerebral vessels with idiopathic expansion of the wall of elastic arteries with the formation of an aneurysm, pathological kinking, loop formation [1-3], as a manifestation of a systemic dysplastic process. Assessments of the clinical manifestations of undifferentiated connective tissue dysplasia (UCTD) can help for early diagnosis with the definition of the characteristics and prognosis of the subarachnoid hemorrhage (SAH) with the definition of further correct management and preventive measures [1,4, 5]. The connective tissue is a basic sort of tissue providing structural and metabolic support for other organs and tissues the body. It is different, compared to other tissues, consists in its composition of a diverse set of components cells, fibers, blood vessels scattered throughout the extracellular matrix. Hereditary connective tissue diseases are among the most common human genetic diseases. However, undifferentiated connective tissue dysplasia is not always detected in persons with cerebrovascular pathology, especially with non-traumatic subarachnoid hemorrhage [4, 5].