Pub Date : 2021-07-07DOI: 10.1101/2021.07.02.21259902
M. Stavrou, S. Solomou, A. Kythreotou, A. Ioannou, Eva Lioutas, Joanna Lioutas, P. Karayiannis
Background The SARS-CoV-2 virus causes a wide spectrum of disease severity. Initial manifestations include fever, dry cough, and constitutional symptoms, which may progress to respiratory disease. There may also be neurological and psychiatric manifestations, involving both the central and peripheral nervous system. Methods We performed a literature search of the databases PubMed, EMBASE, The Cochrane Library and Web of Science for observational studies reporting neurological, psychiatric, and neuropsychiatric effects of COVID-19. This was followed by a narrative synthesis to summarise the data and discuss neuropsychiatric associations, symptom severity, management, and recovery. Findings The most frequently reported neurological symptoms were ageusia, hyposmia/anosmia, dizziness, headache, and loss of consciousness. Statistically significant relationships were noted between Asian ethnicity and peripheral neuropathy (p=0.0001) and neuro-syndromic symptoms (p=0.001). ITU admission was found to have a statistically significant relationship with male sex (p=0.024). Depression and anxiety were also identified both during and after infection. The most frequent treatments used were intravenous immunoglobulins, followed by antibiotics, antivirals, and hydroxychloroquine; with mean treatment duration of 6 days. Interpretation Various neuropsychiatric symptoms have been associated with COVID-19 infection. More studies are required to further our knowledge in the management of neurological and psychiatric symptoms during and after COVID-19 infection
背景:SARS-CoV-2病毒可引起多种严重程度的疾病。最初表现为发热、干咳和体质症状，可发展为呼吸道疾病。也可能有神经和精神方面的表现，包括中枢和周围神经系统。方法:我们在PubMed、EMBASE、Cochrane图书馆和Web of Science数据库中进行文献检索，以获取报道COVID-19神经、精神和神经精神影响的观察性研究。随后进行叙述性综合，总结数据并讨论神经精神病学关联、症状严重程度、管理和恢复。发现最常见的神经系统症状为听觉障碍、嗅觉减退、头晕、头痛和意识丧失。亚裔与周围神经病变(p=0.0001)和神经综合征症状(p=0.001)之间存在统计学上显著的关系。国际电联录取与男性性别有统计学显著关系(p=0.024)。在感染期间和感染后也发现了抑郁和焦虑。最常用的治疗方法是静脉注射免疫球蛋白，其次是抗生素、抗病毒药物和羟氯喹;平均治疗时间6天。各种神经精神症状与COVID-19感染相关。需要更多的研究来进一步了解COVID-19感染期间和之后的神经和精神症状的管理
{"title":"Neurological, neuropsychiatric and psychiatric symptoms during COVID-19 infection and after recovery: a systematic review of observational studies","authors":"M. Stavrou, S. Solomou, A. Kythreotou, A. Ioannou, Eva Lioutas, Joanna Lioutas, P. Karayiannis","doi":"10.1101/2021.07.02.21259902","DOIUrl":"https://doi.org/10.1101/2021.07.02.21259902","url":null,"abstract":"Background The SARS-CoV-2 virus causes a wide spectrum of disease severity. Initial manifestations include fever, dry cough, and constitutional symptoms, which may progress to respiratory disease. There may also be neurological and psychiatric manifestations, involving both the central and peripheral nervous system. Methods We performed a literature search of the databases PubMed, EMBASE, The Cochrane Library and Web of Science for observational studies reporting neurological, psychiatric, and neuropsychiatric effects of COVID-19. This was followed by a narrative synthesis to summarise the data and discuss neuropsychiatric associations, symptom severity, management, and recovery. Findings The most frequently reported neurological symptoms were ageusia, hyposmia/anosmia, dizziness, headache, and loss of consciousness. Statistically significant relationships were noted between Asian ethnicity and peripheral neuropathy (p=0.0001) and neuro-syndromic symptoms (p=0.001). ITU admission was found to have a statistically significant relationship with male sex (p=0.024). Depression and anxiety were also identified both during and after infection. The most frequent treatments used were intravenous immunoglobulins, followed by antibiotics, antivirals, and hydroxychloroquine; with mean treatment duration of 6 days. Interpretation Various neuropsychiatric symptoms have been associated with COVID-19 infection. More studies are required to further our knowledge in the management of neurological and psychiatric symptoms during and after COVID-19 infection","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44686705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-14DOI: 10.32474/OJNBD.2021.05.000217
N. Sulimai, D. Lominadze
Involvement of Fibrinogen(Fg) and fibrin during various pathologies associated with neuroinflammatory diseases associated with memory reduction are well known. Elevated level of Fg, called hyperfibrinogenemia (HFg) (e.g. ≥ 4±0.1 mg/ml of plasma during inflammation vs.~2±0.1 mg/ml of normal plasma [1]), accompanies inflammatory diseases such as stroke [2,3], hypertension [1,4], diabetes [5] and Traumatic Brain Injury (TBI) [6-9]. Blood level of Fg increases during inflammation in general [10].
{"title":"Fibrinogen and/or Fibrin as a Cause of Neuroinflammation.","authors":"N. Sulimai, D. Lominadze","doi":"10.32474/OJNBD.2021.05.000217","DOIUrl":"https://doi.org/10.32474/OJNBD.2021.05.000217","url":null,"abstract":"Involvement of Fibrinogen(Fg) and fibrin during various pathologies associated with neuroinflammatory diseases associated with memory reduction are well known. Elevated level of Fg, called hyperfibrinogenemia (HFg) (e.g. ≥ 4±0.1 mg/ml of plasma during inflammation vs.~2±0.1 mg/ml of normal plasma [1]), accompanies inflammatory diseases such as stroke [2,3], hypertension [1,4], diabetes [5] and Traumatic Brain Injury (TBI) [6-9]. Blood level of Fg increases during inflammation in general [10].","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47430678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fibrinogen and/or Fibrin as a Cause of Neuroinflammation.","authors":"Nurul Sulimai, David Lominadze","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318361/pdf/nihms-1707287.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39259102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-30DOI: 10.32474/ojnbd.2020.04.000199
Kristi L. Kanel
Since the world became familiar with the Pandemic related to the Novel Corona Virus, or COVID 19, most people have experienced...
自从全世界都熟悉了与新型冠状病毒（COVID 19）有关的大流行病以来，大多数人都经历过。。。
{"title":"Understanding PTSD and Depression During the Pandemic Watch","authors":"Kristi L. Kanel","doi":"10.32474/ojnbd.2020.04.000199","DOIUrl":"https://doi.org/10.32474/ojnbd.2020.04.000199","url":null,"abstract":"Since the world became familiar with the Pandemic related to\u0000the Novel Corona Virus, or COVID 19, most people have experienced...","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42268030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-06DOI: 10.32474/ojnbd.2020.04.000198
Sukriti Das, A. Sarker, D. Ghosh, Kanji Fatema Ishrat Zahan, M. S. Khan, A. Khan, B. Chaurasia
Meningiomas were named by Harvey Cushing in 1922 and described as common tumors that arise from arachnoid cap cells...
脑膜瘤是1922年由哈维·库欣命名的，被描述为一种由蛛网膜帽细胞产生的常见肿瘤。
{"title":"Cranio-Cervical Junction Meningioma: A Rare Case Report","authors":"Sukriti Das, A. Sarker, D. Ghosh, Kanji Fatema Ishrat Zahan, M. S. Khan, A. Khan, B. Chaurasia","doi":"10.32474/ojnbd.2020.04.000198","DOIUrl":"https://doi.org/10.32474/ojnbd.2020.04.000198","url":null,"abstract":"Meningiomas were named by Harvey Cushing in 1922 and\u0000described as common tumors that arise from arachnoid cap cells...","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47686244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-09DOI: 10.32474/ojnbd.2020.04.000195
Shairin Sihabdeen, C. Cereda, C. Staedler, G. Chiaro, E. Ventura, M. Manconi
Wallenberg syndrome is the most frequent clinical manifestation of brainstem ischemia, and it is due to lateral...
瓦伦堡综合征是脑干缺血最常见的临床表现，它是由脑干外侧缺血引起的。
{"title":"Co-Occurrence of High Degree Atrioventricular Block and Facial Pain in Lateral Medullary Stroke","authors":"Shairin Sihabdeen, C. Cereda, C. Staedler, G. Chiaro, E. Ventura, M. Manconi","doi":"10.32474/ojnbd.2020.04.000195","DOIUrl":"https://doi.org/10.32474/ojnbd.2020.04.000195","url":null,"abstract":"Wallenberg syndrome is the most frequent clinical\u0000manifestation of brainstem ischemia, and it is due to lateral...","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45537504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-07DOI: 10.32474/ojnbd.2020.04.000193
K. Meguro
I herein present a unique statement, not focusing on the specific area but present an integrated viewpoint through...
我在此提出一个独特的陈述，不专注于特定领域，而是通过……
{"title":"Rhinal Cortices Connecting the Papez and Yakovlev Circuits: An Integrated Viewpoint Through MRI Epidemiology to Animal Experiment for Better Understanding Clinical Features of Alzheimer Disease and Vascular Dementia","authors":"K. Meguro","doi":"10.32474/ojnbd.2020.04.000193","DOIUrl":"https://doi.org/10.32474/ojnbd.2020.04.000193","url":null,"abstract":"I herein present a unique statement, not focusing on the specific area but present an integrated viewpoint through...","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41931431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-06DOI: 10.32474/ojnbd.2020.04.000192
Anil Kumar, N. Rawat, Hemprabha Tainguriya
Transient Receptor Potential (TRP) channels are group of membrane proteins that play a key role in managing variety...
瞬时受体电位（TRP）通道是一组膜蛋白，在管理各种蛋白质中起着关键作用。。。
{"title":"Therapeutic Potential of TRPM Modulator","authors":"Anil Kumar, N. Rawat, Hemprabha Tainguriya","doi":"10.32474/ojnbd.2020.04.000192","DOIUrl":"https://doi.org/10.32474/ojnbd.2020.04.000192","url":null,"abstract":"Transient Receptor Potential (TRP) channels are group of\u0000membrane proteins that play a key role in managing variety...","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46226264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-01DOI: 10.32474/ojnbd.2020.04.000191
J. Pisón, M. Andrés
We pediatric neurologists treat many children with neurodevelopmental disorders and/or epilepsy...
我们的儿科神经科医生治疗许多患有神经发育障碍和/或癫痫的儿童。
{"title":"Synaptopathies, Neurotransmitters and Pharmacological Management of Epilepsy and Neurodevelopmental Disorders","authors":"J. Pisón, M. Andrés","doi":"10.32474/ojnbd.2020.04.000191","DOIUrl":"https://doi.org/10.32474/ojnbd.2020.04.000191","url":null,"abstract":"We pediatric neurologists treat many children with neurodevelopmental disorders and/or epilepsy...","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69690539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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