Designing biphasic gels from dietary fiber sterculia gum by green approach using high energy radiation for biomedical applications

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2023-05-06 DOI:10.1016/j.fhfh.2023.100137
Baljit Singh, Vikrant Sharma, Rajender Kumar, Diwanshi Sharma
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引用次数: 1

Abstract

Polysaccharides have been applied in food and biomedical applications. Bioactive dietary fiber sterculia gum (SG) has been used for treatment of diarrhea. Therefore, in present research, SG has been used for development of drug delivery (DD) system for controlled release of metronidazole to improve its pharmacotherapy for amoebic dysentery. Co-polymers were characterized by Cryo-scanning electron microscopy (Cryo-SEM), atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy, 13C nuclear magnetic resonance (NMR) spectroscopy,), X-ray diffraction (XRD), thermo gravimetric analysis (TGA) and differential scanning calorimetry (DSC). Haemolytic index values of grafted product was less than 5 percent and DPPH assay illustrated free radical scavenging of hydrogels and bigels 74.00 ± 0.003% and 47.00 ± 0.005% respectively. Mucoadhesion experiment demonstrated that both hydrogels and bigels exhibited adhesion with intestinal mucus membrane required 0.034 ± 0.004 and 0.037 ± 0.002 N detachment force during mucoadhesion test. Diffusion of metronidazole was slow in sustained manner with Fickian diffusion mechanism. Overall results revealed biocompatible, antioxidant, and mucoadhesive properties of sterculia gum based gels which may be useful for DD applications of gastrointestinal infections.

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利用高能辐射的绿色方法设计膳食纤维球藻胶双相凝胶用于生物医学应用
多糖已被应用于食品和生物医学领域。生物活性膳食纤维胆胶(SG)已被用于治疗腹泻。因此,本研究利用SG开发甲硝唑控释给药系统,以改善甲硝唑治疗阿米巴痢疾的药物治疗效果。采用低温扫描电镜(cro - sem)、原子力显微镜(AFM)、傅里叶变换红外(FTIR)光谱、13C核磁共振(NMR)光谱、x射线衍射(XRD)、热重分析(TGA)和差示扫描量热法(DSC)对共聚物进行了表征。接枝产物的溶血指数值小于5%,DPPH测定显示水凝胶和凝胶的自由基清除率分别为74.00±0.003%和47.00±0.005%。黏附实验表明,水凝胶和凝胶均与肠粘膜发生黏附,黏附试验时分别需要0.034±0.004和0.037±0.002 N的剥离力。甲硝唑的扩散持续缓慢,具有菲克扩散机制。结果表明,该凝胶具有生物相容性、抗氧化性和黏附性,可用于胃肠道感染的治疗。
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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
0
审稿时长
61 days
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