Food Hydrocolloids for Health最新文献

{"title":"Antimicrobial properties and biomedical potential of zinc oxide nanoparticles in pediatric diarrhea: A narrative review","authors":"Ali Khorsand Zak ,&nbsp;Hadi Khorsand Zak ,&nbsp;Abdul Manaf Hashim","doi":"10.1016/j.fhfh.2026.100266","DOIUrl":"10.1016/j.fhfh.2026.100266","url":null,"abstract":"<div><div>Zinc oxide nanoparticles (ZnO NPs) have been extensively investigated for their antimicrobial activity and potential relevance to pediatric diarrhea, owing to their size-dependent reactivity and ability to generate reactive oxygen species. This review critically examines recent experimental and preclinical studies reporting the antimicrobial effects of ZnO NPs, with particle sizes typically ranging from 10 to 80 nm and effective concentrations between 5 and 200 µg/mL. In vitro studies commonly report bacterial growth inhibition rates of 60–95% against enteric pathogens such as <em>Escherichia coli</em> and Salmonella spp., with smaller particles and surface-modified ZnO NPs showing enhanced activity compared to bulk ZnO and soluble zinc salts. Comparative analysis indicates that ZnO NPs often achieve similar or improved antimicrobial efficacy at lower zinc doses, while also exhibiting variable cytotoxicity depending on particle size, surface chemistry, and exposure duration. However, reported toxicity thresholds overlap with antimicrobial dose ranges, highlighting a narrow therapeutic window. The review further discusses mechanistic insights, including membrane disruption, oxidative stress induction, and ion release, as well as current limitations related to reproducibility, safety assessment, and lack of standardized dosing frameworks. Overall, while ZnO NPs demonstrate promising preclinical antimicrobial performance, their therapeutic applicability in pediatric diarrhea remains contingent upon rigorous in vivo validation and standardized safety evaluation.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"9 ","pages":"Article 100266"},"PeriodicalIF":5.1,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upcycled defatted rice bran in alginate-based noodles enhances postprandial satiety and antioxidant capacity in humans","authors":"Siriyakorn Chantieng,&nbsp;Mutthatinee Tangmongkhonsuk,&nbsp;Waralee Joymak,&nbsp;Nitchakan Chaiprukmalakan,&nbsp;Tanyawan Suantawee,&nbsp;Sathaporn Ngamukote,&nbsp;Charoonsri Chusak,&nbsp;Sirichai Adisakwattana","doi":"10.1016/j.fhfh.2025.100265","DOIUrl":"10.1016/j.fhfh.2025.100265","url":null,"abstract":"<div><div>Defatted rice bran (DRB), a nutrient-rich by-product of rice milling, is an abundant source of fiber and bioactive compounds but has limited direct food applications due to unfavorable sensory attributes. Encapsulation within alginate-based noodles may enhance its stability, functionality, and consumer acceptability. This randomized, controlled, three-period crossover trial investigated the acute effects of DRB-enriched alginate noodles, with or without gelatin, on postprandial satiety, antioxidant responses, and glucose homeostasis in 21 healthy young adults. Participants consumed 240 g of noodles with 150 mL broth in three formulations: alginate only (A), alginate with 5 % DRB (AD), and alginate with 5 % DRB plus 1 % gelatin as a structural enhancer (ADG), with a one-week washout between interventions. Blood samples and appetite ratings were collected at baseline and up to 180 min postprandially. Both DRB-containing formulations significantly increased glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) secretion compared with A, which was accompanied by a marked suppression of hunger and desire to eat, and higher fullness ratings. Plasma antioxidant capacity, assessed by FRAP, TEAC, and thiol assays, was also significantly elevated in AD and ADG relative to A (<em>p</em> &lt; 0.05), while postprandial plasma glucose responses remained stable across treatments. No differences were detected between AD and ADG, indicating that gelatin primarily enhanced noodle structure without altering physiological outcomes. These findings extend recent evidence that upcycling DRB through alginate encapsulation acutely improves satiety hormone responses, appetite regulation, and systemic antioxidant defense without affecting glycemia, supporting its application in the development of sustainable, health-promoting staple foods.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"9 ","pages":"Article 100265"},"PeriodicalIF":5.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food-grade gel systems as emerging platforms in sports nutrition: Structure, applications, challenges, and future directions","authors":"Chunguang Fan ,&nbsp;Ruili Guo ,&nbsp;Junling Liu ,&nbsp;Jian Yang ,&nbsp;Lin Zhang ,&nbsp;Yuhong Cui ,&nbsp;Wei Wang","doi":"10.1016/j.fhfh.2025.100263","DOIUrl":"10.1016/j.fhfh.2025.100263","url":null,"abstract":"<div><div>Food-grade gels are emerging as versatile platforms in sports nutrition, offering advantages beyond conventional liquids and solids through their tunable structures, rheological properties, and controlled release behaviors. This review provides a comprehensive synthesis of current advances, highlighting how protein-, polysaccharide-, and composite-based gels function as nutrient carriers while modulating gastrointestinal dynamics, enzyme accessibility, and molecular interactions to optimize nutrient absorption and bioactive stability. Special attention is given to stimuli-responsive gels, which adapt to physiological triggers such as pH, temperature, ionic strength, and enzymatic activity, enabling spatiotemporal precision in nutrient release. On the application side, evidence supports their roles in pre-exercise energy stabilization, in-exercise carbohydrate–electrolyte delivery, and post-exercise recovery through sustained amino acid supply, glycogen resynthesis, antioxidant protection, and probiotic targeting. Yet, challenges remain regarding formulation optimization, large-scale processing, and personalized strategies that match the diverse metabolic demands of athletes. Looking forward, the integration of AI-driven formulation, multi-stimuli gel systems, and advanced 3D/4D/5D printing technologies promises to accelerate the development of personalized and sustainable gel-based sports nutrition. By bridging structural design with physiological outcomes, this review positions food gels as next-generation platforms to enhance athletic performance and long-term health resilience.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"9 ","pages":"Article 100263"},"PeriodicalIF":5.1,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reformulating gummy candies with carob flour: A nutritional strategy to enhance bioactive compounds and functional properties","authors":"Héctor Gómez-Llorente,&nbsp;María Dolores Ortolá,&nbsp;Isabel Fernández-Segovia,&nbsp;José Manuel Barat,&nbsp;Édgar Pérez-Esteve","doi":"10.1016/j.fhfh.2025.100262","DOIUrl":"10.1016/j.fhfh.2025.100262","url":null,"abstract":"<div><div>The growing demand for healthier foods has driven the development of functional products in the confectionery sector. In this context, carob (<em>Ceratonia siliqua</em> L.), a Mediterranean legume naturally rich in fiber, polyphenols, and D-pinitol, was incorporated into gelatin-based gummies to enhance their nutritional and functional properties. The incorporation of carob flours with different roasting degrees and milling sizes had a significant impact on fiber, D-pinitol, and phenolic content, as well as on antioxidant activity and α-glucosidase inhibitory capacity. Among the tested conditions, the intermediately roasted flour (R2) and industrial milling (R2IM) achieved the best balance between functional, sensory, and safety attributes, showing low levels of hydroxymethylfurfural (HMF) and absence of acrylamide. In vitro digestion assays of the gummies, compared with sugar solutions containing equivalent amounts of carob, revealed that polyphenols were more stable under both gastric and intestinal conditions, whereas D-pinitol exhibited a delayed but more sustained release. These findings would indicate that the protective and modulating effects observed are mainly attributed to the interactions between carob components and the gelatin matrix, which enhance gastrointestinal stability and enable controlled bioactive delivery. Overall, these results highlight the potential of carob as a multifunctional ingredient in gelatin-based confectionery, supporting the development of health-oriented sweets with improved nutritional profile, antioxidant stability, and potential to modulate postprandial glycemia through gradual compound release.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"9 ","pages":"Article 100262"},"PeriodicalIF":5.1,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-function relationships of Alpinia oxyphylla Fruit polysaccharides via different extraction methods: IL-22 pathway activation mediates enhancement of intestinal barrier protection by ultrasound extraction","authors":"Yingzhu He ,&nbsp;Ze Ma ,&nbsp;Hejing Shen ,&nbsp;Bei Fan ,&nbsp;Xiang Li ,&nbsp;Qin Tian ,&nbsp;Fengzhong Wang ,&nbsp;Yajuan Bai","doi":"10.1016/j.fhfh.2025.100261","DOIUrl":"10.1016/j.fhfh.2025.100261","url":null,"abstract":"<div><div>The bioactivity of <em>Alpinia oxyphylla</em> fruit polysaccharides (AFP) is closely linked to their extraction-determined structural properties. This study systematically compared three extraction methods (ultrasound-assisted enzymatic (AFP-UE), pure ultrasound (AFP-U), and hot water (AFP-H)) for their efficiency in extracting AFP and influencing their structural features and intestinal barrier protective effects. Although AFP-UE yielded the highest extraction efficiency (4.75 %) and exhibited predominantly a neutral arabinogalactan, it was AFP-U (comprises mixed rhamnogalacturonan-I and homogalacturonan domains alongside notable glucan motifs) that demonstrated the most potent intestinal barrier protection in a dextran sulfate sodium (DSS)-induced zebrafish colitis model. At 50 μg/mL, AFP-U significantly reduced the pro-inflammatory cytokine TNF-α, while upregulating anti-inflammatory cytokine IL-4, tight junction protein ZO-1, and mucin 2. Mechanistically, AFP-U is very likely to mainly alleviated oxidative stress and promoted intestinal barrier repair primarily by activating the IL-22 pathway, as evidenced by enhanced IL-22/IL-10 expression and suppression of IL-22 Receptor Subunit Alpha-2 (IL-22RA2). These findings highlight the critical role of extraction methods in shaping polysaccharide structure and bioactivity, positioning pure ultrasound extraction as a green and efficient strategy for producing functional polysaccharides with enhanced gastrointestinal health benefits.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"9 ","pages":"Article 100261"},"PeriodicalIF":5.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145735502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colloidal and structural perspectives on seaweed-derived bioactives: Extraction techniques and emerging applications","authors":"Nisha Naghera ,&nbsp;Rushita Parmar ,&nbsp;Dushyant Dudhagara ,&nbsp;Sandip Gamit ,&nbsp;Nirali Nandaniya ,&nbsp;Devangi Chaun ,&nbsp;Ramesh Kothari ,&nbsp;Hari N ,&nbsp;Suhas Vyas","doi":"10.1016/j.fhfh.2025.100260","DOIUrl":"10.1016/j.fhfh.2025.100260","url":null,"abstract":"<div><div>The seaweeds, frequently labeled as macroalgae, can be classified into three vital groups: Chlorophyta (green algae), Phaeophyceae (brown algae), and Rhodophyta (red algae). Marine macroalgae serve as plentiful reservoirs of bioactive elements, comprising polysaccharides, proteins, fats, crucial minerals, vitamins, phenolic substances, and pigments, potentially influencing many sectors. Agar, alginate, carrageenan, fucoidan, polyphenols, and peptides have remarkable roles in promoting health, fighting inflammation, combating microbes, reducing obesity, and preventing cancer, making them essential for enhancing wellness, averting illness, creating functional foods, and developing beauty products. This review examines the extraction of these bioactive substances, which has increasingly employed novel methodologies due to their considerable advantages, such as eco-friendliness, expedited processes, enhanced sustainability, and overall superior efficiency compared to conventional or traditional techniques. To achieve optimal efficiency outcomes for the targeted bioactive compounds, it is imperative to optimize the parameters of novel methods for each specific approach. Furthermore, this investigation illuminates the imaginative applications of seaweed-derived substances, showcasing their significant evolution while emphasizing their structure and prospective applications within the food sector; these seaweeds serve as a basis for developing fertilizers, biofuels, biostimulants, bioplastics, cosmetics, pharmaceuticals, and other biotechnological products, including alginate-based innovations. To enhance understanding of the medicinal potential of seaweeds, recent advancements and challenges pertaining to bioavailability are scrutinized within a pharmaceutical context. Seaweeds are vital for restoring contaminated water and soil, supporting efforts to reduce climate change and encouraging a circular economy, which points to the pressing requirement for further investigation and innovation to fully exploit their broad uses.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"9 ","pages":"Article 100260"},"PeriodicalIF":5.1,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage-targeted liposomes as a nano-immunomodulator for rheumatoid arthritis: Harnessing the therapeutic potential of white asparagus polysaccharides","authors":"Munire Abudurexiti ,&nbsp;Li Chen ,&nbsp;Shuangjiang Cheng ,&nbsp;Rongrui Zhang ,&nbsp;E. Zhang ,&nbsp;Yafei Ma ,&nbsp;Lu Han ,&nbsp;Lili He ,&nbsp;Qiang Liu ,&nbsp;Zhi-xiang Yuan","doi":"10.1016/j.fhfh.2025.100256","DOIUrl":"10.1016/j.fhfh.2025.100256","url":null,"abstract":"<div><div>Therapeutic delivery to inflamed joints remains a critical challenge in rheumatoid arthritis (RA) management due to systemic clearance and nonspecific biodistribution. Within the RA synovial microenvironment, macrophage activation as a central pathogenic mechanism, by exhibit pro-inflammatory M1 polarization, mediating inflammatory progression through sustained secretion of pro-inflammatory cytokines. Removal of M1-phenotype macrophages or their conversion to the M2 phenotype is a promising strategy for the treatment of RA. In this study, asparagus polysaccharides (AP) of white asparagus as a kind of functional foods with therapeutic properties selected as anti-inflammatory agent were encapsulated into liposomes modified withdextran sulfate (DS), a high-affinity ligand for macrophage scavenger receptor-A (SR-A) to construct an actively macrophage-targeted drug delivery system (DS-AP@Lip) for RA targeted therapy. Our results revealed that DS-AP@Lip exhibited a nearly spherical structure with a particle size of 145.2 ± 5.1 nm with low cytotoxicity, high drug loading capacity, good sustained release profile and good stability. The <em>in vitro</em> anti-inflammatory data further showed that DS-AP@Lip were effectively taken up by macrophages with significant anti-inflammatory activity and M2-biased differentiation. In a rat RA model, we found that DS-AP@Lip could preferentially target to macrophages when intravenously administrated and remarkably facilitated AP distribution and retention in inflamed joints. DS-AP@Lip treatment resulted in significant attenuation of synovial inflammation, cartilage erosion, and pro-inflammatory cytokine levels while promoting M2 repolarization. Especially, DS-AP@Lip downregulated the gene expression of p38-MAPK and NF-κB, inhibited the levels of p38-MAPK and NF-κB p65 proteins as well as elevation of the level of iκB protein, indicating that the anti-inflammatory mechanism of DS-AP@Lip should be based on synergistically suppressed NF-κB/MAPK signaling pathways. In conclusion, our work offers a facile approach by utilizing specific receptor-ligand interactions to improve the specific macrophage-targeted ability of the nanocarrier in RA joints and then achieve the precise delivery of AP, enhancing therapeutic efficacy against RA pathogenesis.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100256"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced oral delivery of zeaxanthin via chitosan/alginate nanoparticles: Optimizing stability and antioxidant efficacy in retinal cells","authors":"Feuangthit Niyamissara Sorasitthiyanukarn ,&nbsp;Chawanphat Muangnoi ,&nbsp;Nonthaneth Nalinratana ,&nbsp;Pranee Rojsitthisak ,&nbsp;Pornchai Rojsitthisak","doi":"10.1016/j.fhfh.2025.100254","DOIUrl":"10.1016/j.fhfh.2025.100254","url":null,"abstract":"<div><div>Zeaxanthin (ZT), a lipophilic carotenoid with strong antioxidant potential, suffers from poor aqueous solubility and low oral bioavailability, which limits its therapeutic application. In this study, chitosan/alginate nanoparticles (CS/ALG-NPs) were developed and optimized for oral ZT delivery using a Box-Behnken design. The optimized NPs showed a particle size of 268 ± 35 nm, a zeta potential of −25.2 ± 0.8 mV, and an encapsulation efficiency of 75.4 ± 3.4%. <em>In vitro</em> release under simulated gastrointestinal (GI) conditions exhibited sustained release with improved digestive stability and bioaccessibility compared to free ZT. The optimized ZT-CS/ALG-NPs exhibited favorable stability, maintaining particle size, surface charge, and encapsulation efficiency during storage at 4 °C, and retained their spherical morphology and uniform dispersion after simulated GI digestion, supporting their potential for oral delivery applications. In ARPE-19 cells, ZT-CS/ALG-NPs significantly reduced intracellular reactive oxygen species, restored antioxidant enzyme activities (SOD, CAT, GPx), and increased intracellular glutathione (GSH) levels compared to free ZT. Under H₂O₂-induced oxidative stress, ZT-CS/ALG-NPs reduced the expression of pro-apoptotic proteins (Bax and cytochrome c) and increased the expression of anti-apoptotic protein (Bcl-2) in ARPE-19 cells (<em>vs</em> H₂O₂ group). Transmission electron microscopy and flow cytometry confirmed cellular uptake. These findings demonstrate the potential of CS/ALG-NPs as a polysaccharide-based oral delivery system to enhance the stability, bioaccessibility, and antioxidant efficacy of hydrophobic bioactives such as zeaxanthin.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100254"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the prebiotic potential of dietary fibre concentrates from artichoke, red pepper, cucumber, and carrot by-products","authors":"Ana A. Vaz ,&nbsp;Isabel Odriozola-Serrano ,&nbsp;Gemma Oms-Oliu ,&nbsp;Olga Martín-Belloso ,&nbsp;Gemma Bellí","doi":"10.1016/j.fhfh.2025.100257","DOIUrl":"10.1016/j.fhfh.2025.100257","url":null,"abstract":"<div><div>The agri-food industry exerts a considerable environmental impact while contributing to substantial losses of functional nutrients, particularly dietary fibre. Developing dietary fibre concentrates (DFCs) as novel functional food ingredients offers a dual opportunity: reducing environmental impact and delivering health-promoting prebiotic ingredients. This study evaluated the prebiotic potential of DFCs from artichoke, carrot, cucumber, and red pepper by assessing their impact on targeted gut microbiota composition and short-chain fatty acid (SCFA) production during 48 h of <em>in vitro</em> colonic digestion.</div><div>All DFCs reduced the Firmicutes/Bacteroidetes ratio from 0.5 to 0.8 at 24 h to below 0.4 at 48 h, indicating shifts towards microbial profiles favoring fibre degradation. Artichoke DFC induced the most pronounced effect, markedly stimulating <em>Lactobacillus</em> populations (&gt;100-fold at 24 h and 14-fold increase at 48 h), likely linked to its chlorogenic acid and inulin content. Carrot DFC also promoted <em>Lactobacillus spp</em>. growth at 24 h, while both artichoke and carrot DFCs enhanced <em>Bifidobacterium</em> abundance. SCFA analysis revealed acetic acid as the dominant metabolite, with peak concentrations in cucumber (35.85 mM), red pepper (32.18 mM), and carrot (22.85 mM) fermentations at 48 h. Remarkably, artichoke DFC yielded the highest butyric acid concentration (13.30 mM), a key metabolite for colonocyte energy supply and intestinal barrier integrity.</div><div>These findings establish vegetable-derived DFCs, particularly artichoke and carrot, as promising prebiotic ingredients that can be selectively utilised by microorganisms to confer health benefits, while also highlighting a sustainable strategy to transform agricultural by-products into valuable functional foods ingredients with possible impacts on gut health.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100257"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical nanogel of glutathione and coenzyme Q10 in sodium alginate for chronic and inflammatory skin conditions: A synergistic antioxidant and anti-inflammatory delivery platform","authors":"Samaa Abdullah ,&nbsp;Samar Thiab ,&nbsp;Alaa A. Al-Masud ,&nbsp;Sarah Fahmi Faludah ,&nbsp;Abeer A. Altamimi","doi":"10.1016/j.fhfh.2025.100258","DOIUrl":"10.1016/j.fhfh.2025.100258","url":null,"abstract":"<div><h3>Background</h3><div>Chronic wounds and oxidative stress–related skin disorders, such as diabetic ulcers, burns, surgical wounds, and inflammatory dermatoses, require sustained topical delivery of antioxidant and anti-inflammatory agents. Glutathione (GSH) and Coenzyme Q10 (CoQ10) offer synergistic therapeutic effects but suffer from poor stability and limited skin permeability. This study developed and evaluated a sodium alginate (SA)-based nanogel co-delivering GSH and CoQ10 for enhanced wound healing.</div></div><div><h3>Methods</h3><div>A GSH–CoQ10 complex was prepared via adsorption and characterised using FT-IR, DSC, XRD, and SEM. The complex was incorporated into SA gels at varying concentrations (1.5%, 2.5%, 3.5%), and formulations were analysed for particle size, polydispersity index (PDI), and zeta potential using dynamic light scattering. GSH release was measured using a DTNB assay and fitted to kinetic models. Rheological behaviour, long-term stability (12 months), and morphology (SEM/TEM) were examined. <em>In vivo</em> efficacy was tested in a rat excisional wound model (<em>n</em> = 36), with ELISA quantification of VEGF, TGF-β1, Collagen I, and IL-6.</div></div><div><h3>Results</h3><div>The optimal 2.5% SA nanogel exhibited 122.0 ± 4.9 nm particle size, −40.0 ± 1.3 mV zeta potential, and PDI 0.25 ± 0.02. GSH release reached 72% over 24 h, following Korsmeyer–Peppas kinetics. Rheological analysis indicated pseudoplastic behaviour. The formulation remained stable for 12 months (f₂ = 81.04). <em>In vivo</em>, the nanogel achieved 98.6% wound closure at day 14 and significantly improved collagen synthesis while reducing IL-6 levels.</div></div><div><h3>Conclusion</h3><div>The GSH–CoQ10-loaded SA nanogel offers a stable and effective platform for treating chronic and acute skin injuries through synergistic antioxidant and anti-inflammatory mechanisms.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100258"},"PeriodicalIF":5.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}