Recent advances in the biosynthesis of coumarin and its derivatives

IF 9.1 Q1 ENGINEERING, CHEMICAL Green Chemical Engineering Pub Date : 2023-04-26 DOI:10.1016/j.gce.2023.04.003
Yusong Zou , Yuxi Teng , Joy Li , Yajun Yan
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Abstract

Coumarin and its derivatives, presenting in many organisms (plants, fungi, and bacteria), are critical metabolites composed of fused benzene and α-pyrone rings. With unique biological and chemical properties, coumarin derivatives possess great technological potential in the agrochemicals, pharmaceuticals, food, and cosmetic industries. The increasing demand for coumarin derivatives accelerates the research in biological and chemical synthesis to provide stable and scalable sources of coumarins. However, the complex structures and unknown pathways have limited the progress in the biosynthesis of coumarin derivatives. Here, we summarize recent developments and provide a detailed analysis of coumarin derivative biosynthetic pathways in different organisms.

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香豆素及其衍生物生物合成研究进展
香豆素及其衍生物存在于许多生物体(植物、真菌和细菌)中,是由融合的苯环和α-吡喃酮环组成的重要代谢产物。香豆素衍生物具有独特的生物和化学特性,在农用化学品、医药、食品和化妆品行业中具有巨大的技术潜力。对香豆素衍生物日益增长的需求加速了生物和化学合成方面的研究,以提供稳定和可扩展的香豆素来源。然而,复杂的结构和未知的途径限制了香豆素衍生物生物合成的进展。在此,我们总结了最近的研究进展,并详细分析了不同生物中香豆素衍生物的生物合成途径。
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来源期刊
Green Chemical Engineering
Green Chemical Engineering Process Chemistry and Technology, Catalysis, Filtration and Separation
CiteScore
11.60
自引率
0.00%
发文量
58
审稿时长
51 days
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