Treatment of intracranial aneurysms with Tubridge flow diverter: A single-center experience

Abstract

Objective To evaluate the safety and efficacy of Tubridge flow diverter (TFD) in the treatment of intracranial aneurysms at a single center. Methods The clinical and angiographic data of 139 patients harboring 143 aneurysms treated with TFD between August 2010 and December 2018 at Department of Neurosurgery, Changhai Hospital, Naval Medical University were retrospectively collected and analyzed. Among them, 127 lesions were located in anterior circulation and 16 in posterior circulation. The size of the aneurysms ranged from 2.8-50.0 mm, with the mean size of 16.4 ± 9.2 mm. Clinical and angiographic follow-up were preformed conventionally after treatment with TFD. The clinical outcomes of the patients were evaluated using modified Rankin Scale (mRS). Results Among the 139 patients with 143 intracranial aneurysms, a total of 163 TFD were delivered and implanted successfully. Three patients had acute ischemic stroke after TFD deploymnet.And there were no bleeding complications and no death. The median clinical follow-up time of 109 patients was 29.6 months (range: 5 to 82 months). The mRS of 0 was obtained in 97 patients, mRS of 1 in 10 and mRS of 2 in 2. Procedure-related complications occurred in 3 patients. Angiographic follow-up data were available in 103 patients. The median follow-up time was 13.0 months (range: 6 to 80 months). The complete occlusion rates at 6 months, 12 months, 24 months and last follow-up were 75.7% (78/103), 83.5% (66/79), 92.3%(48/52) and 82.5% (85/103), respectively. Conclusion Tubridge flow diverter seems safe and effective in the treatment of intracranial aneurysms with relatively high success rate and few complications. Key words: Intracranial aneurysm; Endovascular procedures; Flow diverter; Treatment outcome