N. Bouras, Basel F. Alrayes, Salim Mokrane, Hadj Daoud Bouras, M. Holtz, A. Badjah-Hadj-Ahmed
{"title":"Structure of Potential Dithiolopyrrolone Antibiotics Detected from the DART-ToF-MS Spectra of Saccharothrix algeriensis Extract","authors":"N. Bouras, Basel F. Alrayes, Salim Mokrane, Hadj Daoud Bouras, M. Holtz, A. Badjah-Hadj-Ahmed","doi":"10.15255/kui.2021.083","DOIUrl":null,"url":null,"abstract":"Dithiolopyrrolone antibiotics, produced by the Saharan mycelial bacterium Saccharothrix algeriensis , are known for their potent biological activities. Biochemical profiling of S. algeriensis culture extract was done by direct analysis in real time and time-of-flight mass spectrometry (DART-ToF-MS). No other study on dithiolopyrrolones by this technique has been published. Eleven dithiolopyrrolone derivatives: thiolutin, butyryl-pyrrothine/iso-butyryl-pyrrothine, senecioyl-pyrrothine/tigloyl-pyrroth-ine, valeryl-pyrrothine/iso-valeryl-pyrrothine, 2-methyl-3-pentenyl-pyrrothine/2-hexonyl-pyrrothine, iso-hexanoyl-pyrrothine and benzoyl-pyrrothine were characterised by their exact mass measurement and the corresponding molecular formula of each compound. The obtained results confirmed that DART-ToF-MS is an appropriate confirmatory technique for powerful and rapid screening, as well as characterisation of bacterial secondary metabolites.","PeriodicalId":0,"journal":{"name":"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15255/kui.2021.083","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Dithiolopyrrolone antibiotics, produced by the Saharan mycelial bacterium Saccharothrix algeriensis , are known for their potent biological activities. Biochemical profiling of S. algeriensis culture extract was done by direct analysis in real time and time-of-flight mass spectrometry (DART-ToF-MS). No other study on dithiolopyrrolones by this technique has been published. Eleven dithiolopyrrolone derivatives: thiolutin, butyryl-pyrrothine/iso-butyryl-pyrrothine, senecioyl-pyrrothine/tigloyl-pyrroth-ine, valeryl-pyrrothine/iso-valeryl-pyrrothine, 2-methyl-3-pentenyl-pyrrothine/2-hexonyl-pyrrothine, iso-hexanoyl-pyrrothine and benzoyl-pyrrothine were characterised by their exact mass measurement and the corresponding molecular formula of each compound. The obtained results confirmed that DART-ToF-MS is an appropriate confirmatory technique for powerful and rapid screening, as well as characterisation of bacterial secondary metabolites.
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