Seroprevalence of COVID-19 IgM and IgG antibodies among asymptomatic individuals in Khartoum State-2020

Abstract

Pneumonia cases were reported in a hospital in Wuhan, China, on December, 2019.1 After examining throat cultures from patients, the Chinese Center for Disease Control and Prevention stated that these infections were caused by a new form of beta-coronavirus.2 The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has soon emerged from an epidemic outbreak in Wuhan, China3 into a pandemic that has infected over a million people all over the globe. Attempts of social distancing and the pandemic’s systemic effects concern billions of people. SARS-CoV-2 infects host human cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor, which is around 80% related to SARS-CoV.3 COVID-19 is primarily characterized as a respiratory tract infection, although new evidence shows that it should be considered a chronic infection affecting multiple systems, including the cardiovascular, respiratory, gastrointestinal, neurological, hematopoietic, and immune systems. Several reports have looked at the impact of COVID-19 on routine hematology variables in a range of countries.4-6 The precise mechanism of disease transmission is uncertain, but recent studies suggest that it is transmitted from person to person. Droplet-based and contact-based transmission routes are thought to be the most probable.7 Serologic investigations are performed on clinical samples such as blood, saliva, or even tears, in addition to molecular detection. Antibodies to SARS-CoV-2, such as IgA, IgM, and IgG, are defined using COVID-19 serologic assays. They’re focused predominantly on enzyme-linked immunosorbent assays, which are less complicated than molecular studies.8 On December 31, 2019, the People’s Republic of China announced a cluster of unidentified pneumonia cases to the World Health Organization (WHO). This outbreak was caused by a new coronavirus categorized as extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that was also accountable for the Corona Virus Disease 2019 (COVID-19). It has had an effect on over 200 countries and territories all over the globe. More than 26 million people have been infected and nearly 1000,000 have died as of mid-May 2020. The aim of this study was to determine the seroprevalence of COVID19 in Khartoum State.