Assessment of Cognitive Performance in Bipolar Disorder Type I Patients and Their Unaffected Offspring

Q3 Medicine Revista Colombiana de Psiquiatria Pub Date : 2024-07-01 DOI:10.1016/j.rcp.2022.05.004

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Abstract

Patients with bipolar disorder type I (BP-I) often present with impairments in cognitive function. Offspring unaffected by the disorder can also present with cognitive dysfunction. The objective of this study was to compare the cognitive function of BP-I patients, their unaffected offspring (UO) and healthy control subjects (HC).

Methods

Verbal memory, working memory index, processing speed, attention, verbal and phonological fluency and executive function were evaluated through the application of a neuropsychological battery to three groups made up of BP-I patients that attended the Bipolar Disorder Outpatient Clinic of Clínica San Juan de Dios de Manizales [San Juan de Dios de Manizales Clinic] (n = 30), UO (n = 32) and control group (n = 31). The UO group and the control group were matched by gender, age and level of education.

Results

Major differences between the three groups were found in the measures of cognitive functions (except in semantic fluency). The HC group showed better cognitive performance in all the functions. Post-hoc analysis showed similar results in the cognitive performance between BP-I and UO except in verbal learning and executive function tasks where the results were better in UO. A better performance in the control group was found, compared to the UO group, in executive function, attention, working memory, and semantic fluency and phonological areas.

Conclusions

These results indicate that the offspring of patients with BP-I present with cognitive impairments without suffering from the disorder. This suggests that cognitive dysfunction presents without diagnosis and supports the hypothesis that it can correspond to a BP-I endophenotype.

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双相情感障碍I型患者及其未受影响后代的认知表现评估

躁郁症 I 型（BP-I）患者通常会出现认知功能障碍。未受躁狂症影响的后代也可能出现认知功能障碍。本研究旨在比较 I 型双相情感障碍患者及其未受影响的后代（UO）和健康对照组（HC）的认知功能。方法通过对三组躁郁症患者进行神经心理测试，评估他们的言语记忆、工作记忆指数、处理速度、注意力、言语和语音流畅性以及执行功能，这三组患者分别是在马尼萨莱斯圣胡安迪奥斯诊所（San Juan de Dios de Manizales Clinic）躁郁症门诊就诊的躁郁症患者（30 人）、躁郁症患者后代（32 人）和对照组（31 人）。UO 组和对照组的性别、年龄和受教育程度相匹配。结果发现，三组之间在认知功能（语义流畅性除外）的测量方面存在重大差异。HC 组在所有功能上的认知表现都更好。事后分析表明，BP-I 组和 UO 组的认知表现结果相似，但在言语学习和执行功能任务中，UO 组的结果更好。与 UO 组相比，对照组在执行功能、注意力、工作记忆、语义流畅性和语音方面的表现更好。这表明认知功能障碍是在没有确诊的情况下出现的，并支持了认知功能障碍可能与 BP-I 内表型相对应的假设。

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来源期刊

Revista Colombiana de Psiquiatria Medicine-Psychiatry and Mental Health

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Revista Colombiana de Psiquiatría (RCP) is a quarterly official publication of Colombian Psychiatry Association (March, June, September and December) and its purpose is to spread different the knowledge models that currently constitute the theoretical and practical body of our specialty. Psychiatrists, psychiatric residents, non psychiatric physicians, psychologists, philosophers or other health professionals or persons interested in this area can take part in the magazine. This journal publishes original works, revision or updating articles, case reports of all psychiatry and mental health areas, epistemology, mind philosophy, bioethics and also articles about methodology of investigation and critical reading.