Association Studies of DRD2 and COMT Gene Polymorphisms withRisperidone-induced Amenorrhea in Female Schizophrenia Patients

Abstract

Object: To study the association between dopamine D2 receptor (DRD2) and catechol-O-methyltransferase (COMT) gene polymorphisms and the risperidone-induced amenorrhea resulted from hyperprolactinemia in female schizophrenia patients. Patients and methods: According to International Diagnostic and Classification of Diseases tenth edition (ICD-10) criteria, 45 Chinese female schizophrenic patients (25 patients with amenorrhea, and 20 patients with eumenorrhea) were recruited by trained psychiatrists in this study. Sanger sequencing was utilized to determine the DRD2 and COMT genotypes from peripheral venous blood samples. Results: There were no significant differences between amenorrhea patients and eumenorrhea patients in age, disease courses and risperidone dosages (P>0.05). Also, no significant differences were observed in rs6277, rs1079598 and rs4680 polymorphisms between the two groups. Conclusion: These results suggest that DRD2 rs6277, rs1079598 and COMT rs4680 gene polymorphisms show no significant correlation with risperidone-induced amenorrhea in Chinese female schizophrenia patients.