{"title":"2021 Most Influential Bioelectromagnetics Journal Paper Award","authors":"James C. Lin PhD","doi":"10.1002/bem.22416","DOIUrl":null,"url":null,"abstract":"<p>I am pleased to announce the award for 2021 Most Influential <i>Bioelectromagnetics</i> Journal Paper by citation from among primary research articles published between January 2016 and December 2020. The authors of the paper are Jie Tong, Lijun Sun, Bin Zhu, Yun Fan Xingfeng Ma, Liyin Yu, and Jianbao Zhang. The paper is entitled, “Pulsed electromagnetic fields promote the proliferation and differentiation of osteoblasts by reinforcing intracellular calcium transients,” which was published in <i>Bioelectromagnetics</i>, volume 38, no. 7, pp 541–549. October 2017 [Tong et al., <span>2017</span>].</p><p>Abstract: Pulsed electromagnetic fields (PEMF) can be used to treat bone-related diseases, but the underlying mechanism remains unclear, especially the process by which PEMFs initiate biological effects. In this study, we demonstrated the effects of PEMF on proliferation and differentiation of osteoblasts using the model of calcium transients induced by high extracellular calcium. Our results showed that PEMF can increase both the percentage of responding cells and amplitude of intracellular calcium transients induced by high extracellular calcium stimulation. Compared with corresponding extracellular calcium levels, PEMF stimulation increased proliferation and differentiation of osteoblasts and related gene expressions, such as insulin-like growth factor 1, alkaline phosphatase, runt-related transcription factor 2, and osteocalcin, which can be completely abolished by BAPTA-AM. Moreover, PEMF did not affect proliferation and differentiation of osteoblasts if no intracellular calcium transient was present in osteoblasts during PEMF exposure. Our results revealed that PEMF affects osteoblast proliferation and differentiation through enhanced intracellular calcium transients, which provided a cue to treat bone-related diseases with PEMF.</p><p>Each of the authors received a certificate of the award (see Figure 1) from the <i>Bioelectromagnetics</i> Journal during BioEM2022, the Annual BioEM Meeting held in Nagoya, Japan on June 20, 2022. A monetary prize is also associated with the award.</p><p>The Most Influential <i>Bioelectromagnetics</i> Journal Paper Award by citation was established in 2007 to recognize scholarly contributions to the scientific community, and to acknowledge and foster ongoing excellence in scientific discovery and achievement in its field of research endeavor.</p><p>Congratulations to all the authors.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 6","pages":"353-354"},"PeriodicalIF":1.8000,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bem.22416","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioelectromagnetics","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bem.22416","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
I am pleased to announce the award for 2021 Most Influential Bioelectromagnetics Journal Paper by citation from among primary research articles published between January 2016 and December 2020. The authors of the paper are Jie Tong, Lijun Sun, Bin Zhu, Yun Fan Xingfeng Ma, Liyin Yu, and Jianbao Zhang. The paper is entitled, “Pulsed electromagnetic fields promote the proliferation and differentiation of osteoblasts by reinforcing intracellular calcium transients,” which was published in Bioelectromagnetics, volume 38, no. 7, pp 541–549. October 2017 [Tong et al., 2017].
Abstract: Pulsed electromagnetic fields (PEMF) can be used to treat bone-related diseases, but the underlying mechanism remains unclear, especially the process by which PEMFs initiate biological effects. In this study, we demonstrated the effects of PEMF on proliferation and differentiation of osteoblasts using the model of calcium transients induced by high extracellular calcium. Our results showed that PEMF can increase both the percentage of responding cells and amplitude of intracellular calcium transients induced by high extracellular calcium stimulation. Compared with corresponding extracellular calcium levels, PEMF stimulation increased proliferation and differentiation of osteoblasts and related gene expressions, such as insulin-like growth factor 1, alkaline phosphatase, runt-related transcription factor 2, and osteocalcin, which can be completely abolished by BAPTA-AM. Moreover, PEMF did not affect proliferation and differentiation of osteoblasts if no intracellular calcium transient was present in osteoblasts during PEMF exposure. Our results revealed that PEMF affects osteoblast proliferation and differentiation through enhanced intracellular calcium transients, which provided a cue to treat bone-related diseases with PEMF.
Each of the authors received a certificate of the award (see Figure 1) from the Bioelectromagnetics Journal during BioEM2022, the Annual BioEM Meeting held in Nagoya, Japan on June 20, 2022. A monetary prize is also associated with the award.
The Most Influential Bioelectromagnetics Journal Paper Award by citation was established in 2007 to recognize scholarly contributions to the scientific community, and to acknowledge and foster ongoing excellence in scientific discovery and achievement in its field of research endeavor.
我很高兴地宣布，通过引用2016年1月至2020年12月期间发表的主要研究文章，获得2021年最具影响力生物电磁学期刊论文奖。本文作者为童杰、孙立军、朱斌、范云、马兴峰、余立银、张建宝。这篇论文题为“脉冲电磁场通过增强细胞内钙瞬变促进成骨细胞的增殖和分化”，发表在《生物电磁学》第38卷第1期。7，第541-549页。2017.10 [Tong et al.， 2017]。摘要:脉冲电磁场(PEMF)可用于治疗骨相关疾病，但其潜在机制尚不清楚，特别是其启动生物效应的过程。在这项研究中，我们利用高细胞外钙诱导的钙瞬变模型证明了PEMF对成骨细胞增殖和分化的影响。我们的研究结果表明，PEMF可以增加响应细胞的百分比和高细胞外钙刺激引起的细胞内钙瞬态的幅度。与相应的细胞外钙水平相比，PEMF刺激增加了成骨细胞的增殖和分化，并增加了相关基因的表达，如胰岛素样生长因子1、碱性磷酸酶、矮子相关转录因子2和骨钙素，这些基因可以被BAPTA-AM完全消除。此外，如果在PEMF暴露期间成骨细胞中没有细胞内钙瞬态存在，则PEMF不会影响成骨细胞的增殖和分化。我们的研究结果表明，PEMF通过增强细胞内钙瞬变影响成骨细胞的增殖和分化，这为使用PEMF治疗骨相关疾病提供了线索。每位作者在2022年6月20日在日本名古屋举行的BioEM年度会议BioEM2022期间获得了《生物电磁学杂志》颁发的获奖证书(见图1)。奖金也与该奖项相关联。最具影响力生物电磁学期刊论文奖成立于2007年，旨在表彰对科学界的学术贡献，并表彰和促进在其研究领域的科学发现和成就的持续卓越。祝贺所有的作者。
期刊介绍：
Bioelectromagnetics is published by Wiley-Liss, Inc., for the Bioelectromagnetics Society and is the official journal of the Bioelectromagnetics Society and the European Bioelectromagnetics Association. It is a peer-reviewed, internationally circulated scientific journal that specializes in reporting original data on biological effects and applications of electromagnetic fields that range in frequency from zero hertz (static fields) to the terahertz undulations and visible light. Both experimental and clinical data are of interest to the journal''s readers as are theoretical papers or reviews that offer novel insights into or criticism of contemporary concepts and theories of field-body interactions. The Bioelectromagnetics Society, which sponsors the journal, also welcomes experimental or clinical papers on the domains of sonic and ultrasonic radiation.
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