{"title":"Necessary and Sufficient Conditions for Multiple Objective Optimal Regression Designs","authors":"Lucy L. Gao, J. Ye, Shangzhi Zeng, Julie Zhou","doi":"10.5705/ss.202022.0328","DOIUrl":null,"url":null,"abstract":"We typically construct optimal designs based on a single objective function. To better capture the breadth of an experiment's goals, we could instead construct a multiple objective optimal design based on multiple objective functions. While algorithms have been developed to find multi-objective optimal designs (e.g. efficiency-constrained and maximin optimal designs), it is far less clear how to verify the optimality of a solution obtained from an algorithm. In this paper, we provide theoretical results characterizing optimality for efficiency-constrained and maximin optimal designs on a discrete design space. We demonstrate how to use our results in conjunction with linear programming algorithms to verify optimality.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.5705/ss.202022.0328","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
We typically construct optimal designs based on a single objective function. To better capture the breadth of an experiment's goals, we could instead construct a multiple objective optimal design based on multiple objective functions. While algorithms have been developed to find multi-objective optimal designs (e.g. efficiency-constrained and maximin optimal designs), it is far less clear how to verify the optimality of a solution obtained from an algorithm. In this paper, we provide theoretical results characterizing optimality for efficiency-constrained and maximin optimal designs on a discrete design space. We demonstrate how to use our results in conjunction with linear programming algorithms to verify optimality.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.