Abdul Hakim Md Yusop , Murni Nazira Sarian , Fatihhi Szali Januddi , Hadi Nur
{"title":"Drug-device systems based on biodegradable metals for bone applications: Potential, development and challenges","authors":"Abdul Hakim Md Yusop , Murni Nazira Sarian , Fatihhi Szali Januddi , Hadi Nur","doi":"10.1016/j.bbe.2022.11.002","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Drug-device systems based on biodegradable metals have been of great interest in the last decade due to their local-release regime and the ability of the biodegradable metals to degrade in the physiological environment facilitating tissue growth and gradual load transfer. The </span>biodegradability of the biodegradable metals provides a promising medium that might enable other materials – such as drugs, </span>bioactive materials and therapeutic agents - to be incorporated into the degradable metals to act as a drug-device system that would locally release the drugs or therapeutic agents onto the healing tissue. In comparison to systemic drug delivery, the locally released drug-device system makes the dose control over a specific targeted tissue more efficient and reduces the side effects on non-targeted tissues. This review outlines the current state of development of the biodegradable metals-based drug-device system and focuses in-depth on the potential interactions between the drugs, degradable metallic surfaces, drug carriers, ions and proteins inside the body fluids, which can be a challenge to producing a highly efficient drug-device system.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"43 1","pages":"Pages 42-57"},"PeriodicalIF":5.3000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biocybernetics and Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0208521622000985","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 2
Abstract
Drug-device systems based on biodegradable metals have been of great interest in the last decade due to their local-release regime and the ability of the biodegradable metals to degrade in the physiological environment facilitating tissue growth and gradual load transfer. The biodegradability of the biodegradable metals provides a promising medium that might enable other materials – such as drugs, bioactive materials and therapeutic agents - to be incorporated into the degradable metals to act as a drug-device system that would locally release the drugs or therapeutic agents onto the healing tissue. In comparison to systemic drug delivery, the locally released drug-device system makes the dose control over a specific targeted tissue more efficient and reduces the side effects on non-targeted tissues. This review outlines the current state of development of the biodegradable metals-based drug-device system and focuses in-depth on the potential interactions between the drugs, degradable metallic surfaces, drug carriers, ions and proteins inside the body fluids, which can be a challenge to producing a highly efficient drug-device system.
期刊介绍:
Biocybernetics and Biomedical Engineering is a quarterly journal, founded in 1981, devoted to publishing the results of original, innovative and creative research investigations in the field of Biocybernetics and biomedical engineering, which bridges mathematical, physical, chemical and engineering methods and technology to analyse physiological processes in living organisms as well as to develop methods, devices and systems used in biology and medicine, mainly in medical diagnosis, monitoring systems and therapy. The Journal''s mission is to advance scientific discovery into new or improved standards of care, and promotion a wide-ranging exchange between science and its application to humans.