Chitosan-Based Nanocarriers for Delivery of Remdesivir

IF 2.3 Q3 PHARMACOLOGY & PHARMACY Scientia Pharmaceutica Pub Date : 2023-08-09 DOI:10.3390/scipharm91030037
V. Milkova, K. Kamburova, Petar Martinov, Neli Vilhelmova-Ilieva, Viktor Rashev
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引用次数: 1

Abstract

Stable multicomponent capsules for the delivery of remdesivir (Veklury®) are produced through subsequent electrostatic adsorption of oppositely charged components on oil emulsion droplets. For the first time, the encapsulation and release of the medicine Veklury® from polymer capsules was reported. In this study, the effect of the physicochemical properties of chitosan on the size and stability of the produced structures is investigated, on the loaded amount of drug and on the kinetics of drug release in conditions close to the physiological ones. Microbiological studies of the capsules and their constituents were performed via in vitro assays against HCT-8 cell lines and human coronavirus HCoV-OC43. A detailed analysis was performed on the influence of the properties of produced capsules on cytotoxicity against the chosen cell line, as well as their effect on the replication cycle of the virus, the virucidal activity of the samples against the viability of the extracellular virions, and their effect on viral adsorption on the cell membrane.
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壳聚糖纳米载体递送瑞德西韦
用于递送remdesivir (Veklury®)的稳定多组分胶囊是通过随后在油乳剂液滴上静电吸附带相反电荷的组分而生产的。首次报道了高分子胶囊Veklury®药物的包封和释放。在接近生理条件下,研究了壳聚糖的理化性质对制备结构的大小、稳定性、载药量和药物释放动力学的影响。通过体外对HCT-8细胞系和人冠状病毒HCoV-OC43进行微生物学研究。详细分析了所生产的胶囊性质对所选细胞系的细胞毒性的影响,以及它们对病毒复制周期的影响,样品对细胞外病毒粒子活力的杀病毒活性,以及它们对病毒在细胞膜上吸附的影响。
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来源期刊
Scientia Pharmaceutica
Scientia Pharmaceutica Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.60
自引率
4.00%
发文量
67
审稿时长
10 weeks
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