New halimane and clerodane diterpenoids from Croton cnidophyllus

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2023-07-06 DOI:10.1007/s13659-023-00386-z

Xun Wei, Jia-Luo Huang, Hua-Hua Gao, Fang-Yu Yuan, Gui-Hua Tang, Sheng Yin

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Abstract

Three new halimane furanoditerpenoids (1–3) and three new clerodane furanoditerpenoids (4–6), along with seven known terpenoids including four pimarane diterpenoids (7–10) and three norisoprenoids (11–13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (1–6) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (8 and 9) possessed certain inhibitory effects against NO production stimulated by LPS, with IC₅₀ values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.

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巴豆刺叶属新盐烷和氯烷二萜

从巴豆95% EtOH提取物中分离得到3个新的卤烷类呋喃二萜(1-3)和3个新的氯烷类呋喃二萜(4-6)，以及4个已知的海玛烷类二萜(7-10)和3个异戊二萜(11-13)。通过对新呋喃二萜(1-6)的HRMS和NMR数据的分析，以及实验和计算ECD曲线的比较，确定了它们的二维结构，包括绝对构型。生物实验结果表明，化合物8和9对LPS刺激NO生成具有一定的抑制作用，IC50值分别为19.00±1.76 μM和21.61±1.11 μM。图形抽象

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