A study on the anti-skin tumor and anti-UVB damage effects of Gastrodia elata Bl. Products transformed by Armillaria mellea

IF 1.7 3区农林科学 Q3 CHEMISTRY, APPLIED Food and Agricultural Immunology Pub Date : 2022-09-19 DOI:10.1080/09540105.2022.2120853

Tong Zheng, Yugang Gao, Zhilong Zhang, Xinyue Li, P. Zang, Yan Zhao, Zhongmei He

引用次数: 0

Abstract

ABSTRACT Skin cancer is a malignant tumour that can spread in the skin and is a serious threat to human health. Excessive ultraviolet radiation is one of the most common factors that leads to skin cancer. The purpose of this study was to evaluate the anti-skin tumour and anti-UVB damage effects of Armillaria mellea (Vahl) P. Kumm transformed Gastrodia elata Bl products (ATGP). Gastrodia elata Blume f.glauca S. Chows from Changbai Mountain and 4 Armillaria mellea (Vahl) P. Kumm strains were used as experimental materials. First, the optimum fungal strains of Armillaria mellea used to transform gastrodin were screened. Then, the MTT assay and scratch test proved that ATGP had anti-B16 melanoma cell activity in vitro. Furthermore, the anti-UVB damage effect of ATGP was proven by a UVB damage mouse skin model and HaCat photoaging model, and its mechanism was preliminarily discussed. GRAPHICAL ABSTRACT

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蜜环菌转化天麻制品抗皮肤肿瘤和UVB损伤作用的研究

摘要皮肤癌症是一种可在皮肤中扩散的恶性肿瘤，严重威胁人类健康。过度的紫外线辐射是导致癌症的最常见因素之一。本研究的目的是评估蜜环菌（Vahl）P.Kumm转化的天麻Bl产品（ATGP）的抗皮肤肿瘤和抗UVB损伤作用。以长白山天麻（Gastrodia elata Blume f.glauca S.Chows）和4株蜜环菌（Armillaria mellea（Vahl）P.Kumm）为试验材料。首先，筛选了蜜环菌转化天麻素的最佳菌株。MTT法和划痕试验证明ATGP在体外具有抗B16黑色素瘤细胞的活性。此外，通过UVB损伤小鼠皮肤模型和HaCat光老化模型验证了ATGP的抗UVB损伤作用，并初步探讨了其作用机制。图形摘要

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来源期刊

Food and Agricultural Immunology 农林科学-毒理学

CiteScore

5.30

自引率

6.70%

发文量

审稿时长

2 months

期刊介绍： Food and Agricultural Immunology is an international open access journal publishing original immunological research with applications in food, agricultural, environmental and veterinary science. Submissions describing the use of immunological techniques and methods are particularly welcomed. The journal aims to expand our understanding of the interactions at the interface of food and immune systems including studies on: -Development of diagnostic systems – all types of ligand-based assays, e.g. antibody, aptamer -Application of ligand-based assays for the detection or identification of molecules of interest in food science, agricultural research, veterinary investigations and clinical systems relating to food allergy or sensitivity to agricultural chemicals -Effects of food on the immune system -Studies on allergy and allergic reactions -Investigations into food allergies -Development of allergen-free food systems -Development of novel assay formats -Applications of assay systems to the monitoring of food items in relation to safety and labelling -Food quality issues, e.g. speciation, adulteration and contamination -Comparisons between different analytical techniques The journal publishes research and review articles and is essential reading for food scientists, immunologists and all those concerned with the interaction between food and immune systems.