Molecular phylogenomic analysis reveals a single origin of monkeypox virus transmission in Guangzhou, China in June 2023

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Biosafety and Health Pub Date : 2023-10-01 DOI:10.1016/j.bsheal.2023.08.002

Mengling Jiang , Xizi Deng , Qinghong Fan , Fei Gu , Huiqin Yang , Jian Wang , Xiaoping Tang , Fengyu Hu , Yun Lan , Feng Li

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Abstract

The monkeypox (mpox) virus has caused worldwide transmission since its initial report in England in early May 2022. Available data from the World Health Organization (WHO) show that Europe and the Americas experienced a huge wave of mpox virus infection. Now the number of infected cases is on the rise in Asia. Several sporadic infections have been reported in China. In this study, we obtained high-quality whole viral genomic sequences using a mpox virus-specific amplicon-based sequencing strategy. Our analysis of the phylogenomic characteristics indicated that all eight mpox virus sequences from Guangzhou belonged to the clade IIb lineage B.1.3 cluster. However, we could not locate the exact origins where the virus was imported, based on all the available mpox virus sequences from the Global Initiative on Sharing Avian Influenza Data (GISAID) database (https://gisaid.org/), except for their closest sequence similarity to that was reported from Japan. Novel amino acid mutations were found among the eight cases, suggesting that a local transmission may have occurred in Guangzhou, China.

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分子系统发育分析揭示了2023年6月中国广州猴痘病毒传播的单一起源

自2022年5月初在英格兰首次报告以来，猴痘（猴痘）病毒已在全球范围内传播。世界卫生组织（世界卫生组织）的现有数据显示，欧洲和美洲经历了一次巨大的猴痘病毒感染浪潮。现在，亚洲的感染病例数量呈上升趋势。中国报告了几例散发性感染病例。在这项研究中，我们使用基于猴痘病毒特异性扩增子的测序策略获得了高质量的全病毒基因组序列。我们的系统发育特征分析表明，8个猴痘病毒序列均属于分支IIb谱系B.1.3簇。然而，根据全球禽流感数据共享倡议（GISAID）数据库中所有可用的猴痘病毒序列，我们无法找到病毒输入的确切来源(https://gisaid.org/)，除了它们与日本报道的序列最相似之外。在8例病例中发现了新的氨基酸突变，这表明中国广州可能发生了本地传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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