MECHANISMS OF ROSACEA PATHOGENESIS. A PHENOTYPIC APPROACH TO THERAPEUTIC TACTICS. DEMONSTRATION OF A CLINICAL CASE

Q4 Medicine Vestnik dermatologii i venerologii Pub Date : 2022-11-01 DOI:10.25208/vdv1310
M. Drozhdina, V. Bobro
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引用次数: 1

Abstract

Rosacea is a widespread disease among the population, infected 5.5%. It is known that the activation of the innate and susceptible immune system, as well as neurovascular dysregulation underlying the manifestation of rosacea signs, do not fully explain all the clinical peculiarities of this disease. This dictates the prospect of continuing the diagnostic search and the therapeutic approach with the personalization of management tactics individually for the patient, depending on the prevalence of the manifestation of the characteristics of the course of the disease. A genetic predisposition to modified immune reactivity suggests an association of rosacea with single nucleotide polymorphisms in genes associated with the major histocompatibility complex. Currently, rosacea is considered as a single disease with several main phenotypes: facial erythema, telangiectasias, papulo-pustular manifestations, phimosis and ophthalmic rosacea. Most experts tend to think about the phenotypic approach in modern rosacea therapy, which should be aimed at achieving an improvement in the patient's overall well-being, focusing on those aspects that are most disturbing to the patient, based on the principles of evidence-based medicine. A clinical case of a patient with a papulo-pustular rosacea phenotype is presented. The high effectiveness of the therapy with systemic isotretinoin and topical support in the form of metronidazole and tacrolimus was demonstrated.
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酒渣鼻发病机制。治疗策略的表型方法。临床病例证明
酒渣鼻是一种广泛存在于人群中的疾病,感染率为5.5%。众所周知,先天和易感免疫系统的激活,以及酒渣鼻症状表现背后的神经血管失调,并不能完全解释这种疾病的所有临床特点。这决定了继续进行诊断研究和治疗方法的前景,根据疾病病程特征的表现的普遍性,对患者单独采取个性化的管理策略。免疫反应性改变的遗传易感性提示酒渣鼻与主要组织相容性复合体相关基因的单核苷酸多态性有关。目前,酒渣鼻被认为是一种单一的疾病,具有几种主要的表型:面部红斑、毛细血管扩张、丘疹-脓疱表现、包茎和眼部酒渣鼻。大多数专家倾向于考虑现代酒渣鼻治疗中的表型方法,该方法应以实现患者整体健康的改善为目标,重点关注那些最困扰患者的方面,基于循证医学原则。一个临床病例的患者丘疹脓疱酒渣鼻表现型提出。系统异维甲酸和局部支持形式的甲硝唑和他克莫司治疗的高有效性被证明。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
40
审稿时长
8 weeks
期刊最新文献
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