The Efficacy of Surgicel Compared with Simple Gauze Packing in Grade IV Liver Laceration; A New Hope for Trauma Patients: An Experimental Study

Journal of trauma & treatment Pub Date : 2017-08-04 DOI:10.4172/2167-1222.1000387

H. Khoshmohabat, A. Makarem, M. Karami, H. Rasouli, Z. Danial, Golnoosh Mahmoodizade, Rohallah Rezaei, Shahram Paydar, Seyede Niloofar Dastgheib, Seyed Ali Hossein Zahraei, Z. Shayan

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Abstract

Background: The useful surgical hemostasis agent using in patients with grade 4 of the liver laceration is a challenging problem. This study assessed a topical hemostatic agent (Surgicel) using a partial hepatic laceration hemorrhage model. This experimental study compared the hemostatic effects of Surgicel and conventional gauze packing in hepatic parenchymal bleedings. Methods: Twenty male Wistar albino rats (weight 250 ± 50 g) were randomly divided into two groups. Within each treatment group, surgicel or gauze packing (GP) (n=10/group) was applied to the liver laceration site that was created in the large lobe of the liver. Results: There was statistically significant difference between two groups regarding the changes of before and after operation of HCO3 (P=0.019). Across two groups, rats receiving surgicel lost less blood and formed clots more frequently than GP (p<0.001). Conclusion: Surgicel may be useful to treat hemorrhage from Liver lacerations in trauma patients.

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外科手术与单纯纱布填塞治疗IV级肝裂伤的疗效比较创伤患者的新希望:一项实验研究

背景:在4级肝裂伤患者中使用有效的手术止血剂是一个具有挑战性的问题。本研究使用局部肝裂伤出血模型评估局部止血剂(Surgicel)。本实验研究比较了外科纱布与常规纱布填塞在肝实质出血中的止血效果。方法:雄性Wistar白化大鼠20只，体重250±50 g，随机分为两组。在每个治疗组中，在肝大叶形成的肝裂伤部位应用外科手术或纱布填充物(GP) (n=10/组)。结果:两组患者术前、术后HCO3变化差异有统计学意义(P=0.019)。在两组中，接受手术的大鼠失血量更少，形成血栓的频率高于GP (p<0.001)。结论:手术治疗创伤性肝裂伤出血是有效的。

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