HYDROGEL ANTIBACTERIAL COATING FOR SILICONE MEDICAL DEVICES

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2021-09-30 DOI:10.15259/pcacd.26.012
Kamil Kopeć, Michał Żuk, T. Ciach
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Abstract

Effective antibacterial coatings are in demand in medicine, especially for urological medical devices such as catheters and stents. We propose the production method of an antibacterial hydrogel coating on polydimethylsiloxane (PDMS, silicone), a popular surface for medical materials. The coating process consists of the following steps: PDMS surface activation (introduction of hydroxyl groups), silanisation (introduction of amine groups) and application of chitosan/alginate hydrogel with the addition of lysozyme as an antibacterial agent using the layer-by-layer method. We investigated the effect of polyion concentration on the coating mass, swelling ratio and stability. We analysed the adsorption of Micrococcus luteus, Escherichia coli and Proteus rettgeri on a PDMS surface using confocal laser scanning microscopy. The chitosan/alginate hydrogel coating with immobilised lysozyme protected the PDMS surface against adhesion for all three tested bacterial strains.
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硅胶医疗器械用水凝胶抗菌涂层
有效的抗菌涂层在医学上是有需求的,尤其是用于泌尿外科医疗设备,如导管和支架。我们提出了在医用材料的常用表面聚二甲基硅氧烷(PDMS,硅酮)上制备抗菌水凝胶涂层的方法。涂层工艺包括以下步骤:PDMS表面活化(引入羟基)、硅烷化(引入胺基)和使用逐层法添加溶菌酶作为抗菌剂的壳聚糖/海藻酸盐水凝胶的应用。研究了聚离子浓度对涂层质量、溶胀率和稳定性的影响。我们使用共聚焦激光扫描显微镜分析了黄微球菌、大肠杆菌和雷特氏变形杆菌在PDMS表面的吸附。具有固定化溶菌酶的壳聚糖/藻酸盐水凝胶涂层保护PDMS表面免受所有三种测试菌株的粘附。
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来源期刊
CiteScore
1.10
自引率
16.70%
发文量
19
期刊介绍: Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.
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