Polymorphic Variants across Population of the Growth Hormone Receptor with Mandible Prognathism: A Systematic Review

Q4 Dentistry European Journal of General Dentistry Pub Date : 2022-09-01 DOI:10.1055/s-0042-1759752

S. Sadputranto, A. Maskoen, A. Laviana, E. Sjamsudin

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Abstract

Abstract Genetic influences are critical for determining mandibular protrusion in class IIImalocclusion cases, and growth hormone receptors (GHRs) are thought to have an essential impact on craniofacial bone growth. This review aimed to assess the association between GHR gene polymorphism variants and mandibular morphology. Studies were extensively searched using PubMed and Google Scholar until December 2020. The study design according to PECOS was: P, class III malocclusion; E, GHR polymorphism; no polymorphism in C, GHR; O, linear dimensional changes in maxillary and mandibular measurements; and S, cross-sectional and case-control studies. Selected studies were of acceptable methodological quality on a 10-point scale. A preliminary search identified 107 studies; after excluding duplicate abstracts, 63 studies were screened. Nine studies were subsequently included in the systematic review. Conclusion Polymorphic variants at rs6180, rs6182, and rs6184 in the GHR gene were associated with condylion-gonion measures in Asians and Turks but not in Colombians and Egyptians.

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生长激素受体与下颌骨前突症的多态变异:一项系统综述

摘要基因影响对确定III类错牙合病例的下颌前突至关重要，生长激素受体（GHRs）被认为对颅面骨生长有重要影响。本综述旨在评估GHR基因多态性变异与下颌形态之间的关系。在2020年12月之前，使用PubMed和Google Scholar对研究进行了广泛搜索。根据PECOS的研究设计为：P，III类错牙合；E、 GHR多态性；C、GHR无多态性；O、上颌和下颌测量的线性尺寸变化；和S，横断面和病例对照研究。选定的研究在10分制上具有可接受的方法学质量。初步搜索确定了107项研究；排除重复摘要后，筛选出63项研究。9项研究随后被纳入系统综述。结论GHR基因rs6180、rs6182和rs6184多态性变异与亚洲人和土耳其人的髁突角测量有关，但与哥伦比亚人和埃及人无关。

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European Journal of General Dentistry Dentistry-Dentistry (all)

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1.00

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0.00%

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期刊介绍： European Journal of General Dentistry (EJGD) is one of the leading open-access international dental journal within the field of Dentistry. The aim of EJGD is publishing novel and high-quality research papers, as well as to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. EJGD publishes articles on all disciplines of dentistry including the cariology, orthodontics, oral surgery, preventive dentistry, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research.Moreover, EJGD also publish the scientific researches evaluating the use of new biomaterials, new drugs and new methods for treatment of patients with different kinds of oral and maxillofacial diseases or defects, the diagnosis of oral and maxillofacial diseases with new methods, etc. Moreover, researches on the quality of life, psychological interventions, improving disease treatment outcomes, the prevention, diagnosis and management of cancer therapeutic complications, rehabilitation, palliative and end of life care, and support teamwork for cancer care and oral health care for old patients are also welcome. EJGD publishes research articles, case reports, reviews and comparison studies evaluating materials and methods in the all fields of related to dentistry.