What should be considered during epicutaneous patch testing?

Q3 Medicine Allergo Journal International Pub Date : 2023-02-02 DOI:10.1007/s40629-023-00243-y

Richard Brans, Vera Mahler

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引用次数: 0

Abstract

Indications for epicutaneous patch testing include the detection or exclusion of allergic contact dermatitis of the skin, transitional mucosa or oral mucosa, suspected delayed-type immune reactions to ingredients of implants, and certain drug reactions (maculopapular exanthema, symmetrical drug-related intertriginous and flexural exanthema [SDRIFE], acute generalized exanthematous pustulosis [AGEP], and fixed drug eruption). When available, allergen preparations that have been pharmaceutically tested and that are approved or marketable as medicinal products should be used. Existing diagnostic gaps can be closed by testing the patient’s own materials in a suitable preparation. Interferences of ultraviolet (UV) light exposure or drugs with patch test reactions have to be considered. In addition to the reading after 48 h and 72 h, a further reading between day 7 (168 h) and day 10 (240 h) is useful, since about 15% of the positive test reactions remain undetected without this late reading. All positive patch test reactions considered allergic must be evaluated with regard to their clinical relevance based on existing exposures.

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在皮贴测试过程中应该考虑什么？

表皮贴剂测试的适应症包括检测或排除皮肤、过渡粘膜或口腔粘膜的过敏性接触性皮炎、对植入物成分的疑似延迟型免疫反应，以及某些药物反应（斑丘疹、对称性药物相关性原发性和弯曲性皮疹[SDRIFE]、急性全身性发疹性脓疱病[AGEP]和固定性药疹）。在可用的情况下，应使用经过药物测试并作为药品批准或可销售的过敏原制剂。现有的诊断差距可以通过在合适的制剂中测试患者自己的材料来弥补。必须考虑紫外线（UV）照射的干扰或具有贴片试验反应的药物。除了48后的读数 h和72 h、第7天（168小时）至第10天（240小时）之间的进一步读数是有用的，因为如果没有这种延迟读数，大约15%的阳性检测反应仍然未被检测到。所有被视为过敏的阳性贴片试验反应都必须根据现有暴露情况评估其临床相关性。

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来源期刊

Allergo Journal International Medicine-Immunology and Allergy

CiteScore

4.60

自引率

0.00%

发文量

期刊介绍： Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies. All submissions are reviewed in single-blind fashion by at least two reviewers. Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.