Role of the MBP protein in myelin formation and degradation in the brain

Q3 Agricultural and Biological Sciences Biological Communications Pub Date : 2022-06-24 DOI:10.21638/spbu03.2022.206
A. Shenfeld, Alexey Galkin
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Abstract

The compact myelin sheath functions as an insulator for efficient conduction of nerve impulses. The formation of myelin sheaths around the axons of the most actively functioning neurons continues not only at the stage of brain development, but also in the process of learning and acquiring certain skills. Pathological or age-related disruption in myelin results in nerve conduction failure and neurodegeneration. Myelin Basic Protein (MBP) is the main constituent of the myelin sheath, representing about 30 % of the total myelin proteins in the central nervous system. Deletion in the MBP coding gene in mutant mice causes a severe neurological phenotype associated with rapid death of newborns. In this review, we discuss the current understanding of the role of the MBP protein in the formation of compact myelin and in neurodegeneration associated with demyelination.
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MBP蛋白在脑髓鞘形成和降解中的作用
致密的髓鞘起到绝缘体的作用,用于神经脉冲的有效传导。功能最活跃的神经元轴突周围髓鞘的形成不仅在大脑发育阶段持续,而且在学习和获得某些技能的过程中也会持续。髓鞘的病理性或与年龄相关的破坏会导致神经传导衰竭和神经退行性变。髓鞘碱性蛋白(MBP)是髓鞘的主要成分,约占中枢神经系统髓鞘蛋白总量的30%。突变小鼠MBP编码基因的缺失导致与新生儿快速死亡相关的严重神经表型。在这篇综述中,我们讨论了目前对MBP蛋白在致密髓鞘形成和与脱髓鞘相关的神经退行性变中的作用的理解。
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来源期刊
Biological Communications
Biological Communications Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)
CiteScore
1.70
自引率
0.00%
发文量
21
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